PT - JOURNAL ARTICLE AU - Mao, Jun J. AU - Armstrong, Katrina AU - Bowman, Marjorie A. AU - Xie, Sharon X. AU - Kadakia, Rachel AU - Farrar, John T. TI - Symptom Burden Among Cancer Survivors: Impact of Age and Comorbidity AID - 10.3122/jabfm.2007.05.060225 DP - 2007 Sep 01 TA - The Journal of the American Board of Family Medicine PG - 434--443 VI - 20 IP - 5 4099 - http://www.jabfm.org/content/20/5/434.short 4100 - http://www.jabfm.org/content/20/5/434.full SO - J Am Board Fam Med2007 Sep 01; 20 AB - Background: Previous research among specific cancer populations has shown high but variable symptom burden; however, very little is known about its extent and pattern among the entire population of US cancer survivors, which is more clinically relevant to primary care physicians.Methods: To determine the prevalence of ongoing symptom burden among cancer survivors and compare it with the general population without cancer, we analyzed data from the 2002 National Health Interview Survey, which included 1,904 cancer survivors and 29,092 controls. Main outcome measures included self-reported ongoing pain, psychological distress, and insomnia. Multivariate logistic regression models were used to adjust for confounders and test for interactions.Results: The rates of ongoing pain, psychological distress, and insomnia among cancer survivors were 34%, 26%, and 30%, respectively, and were significantly higher (all P < .001) than controls without a history of cancer (18%, 16%, and 17%). Compared with controls in the same age groups, younger survivors (younger than 50) were much more likely to report ongoing symptoms than older survivors (older than 64); adjusted odds ratios were 2.96 and 1.36 for pain in the respective age groups (P < .001). Comorbidities also interact with cancer status and contribute to a marked increase in reports of ongoing symptom burden among cancer survivors, with a greater number of comorbidities leading to greater degree of symptom burden in a dose-dependent manner (P < .001).Conclusions: The symptom burden among cancer survivors on a population level is substantial and can be impacted by other comorbidities. Thus, engaging primary care physicians in the design, testing, and implementation of effective interventions is important to reduce the symptom burden among cancer survivors.