PT - JOURNAL ARTICLE AU - Wissam Saliba AU - Boutros El-Haddad TI - Secondary Hyperparathyroidism: Pathophysiology and Treatment AID - 10.3122/jabfm.2009.05.090026 DP - 2009 Sep 01 TA - The Journal of the American Board of Family Medicine PG - 574--581 VI - 22 IP - 5 4099 - http://www.jabfm.org/content/22/5/574.short 4100 - http://www.jabfm.org/content/22/5/574.full SO - J Am Board Fam Med2009 Sep 01; 22 AB - Secondary hyperparathyroidism is a frequently encountered problem in the management of patients with chronic kidney disease (CKD). Its pathophysiology is mainly due to hyperphosphatemia and vitamin D deficiency and resistance. This condition has a high impact on the mortality and morbidity of dialysis patients. Early diagnosis of secondary hyperparathyroidism is crucial in the management of patients with CKD. The treatment remains a challenge for patients and their clinicians. It should include a combination of dietary phosphorus restriction, phosphate binders, vitamin D analogues, and calcimimetics.