RT Journal Article SR Electronic T1 Efficacy, Safety, and Tolerability of Low-Dose Hormone Therapy in Managing Menopausal Symptoms JF The Journal of the American Board of Family Medicine JO J Am Board Fam Med FD American Board of Family Medicine SP 563 OP 573 DO 10.3122/jabfm.2009.05.080134 VO 22 IS 5 A1 Langer, Robert D. YR 2009 UL http://www.jabfm.org/content/22/5/563.abstract AB Use of the lowest clinically effective dose of postmenopausal hormone therapy conforms to current recommendations and good clinical practice. Although accumulating evidence demonstrates the efficacy and tolerability of low hormone therapy doses, data about their use are limited by a lack of long-term, randomized studies. This review evaluates current evidence on the efficacy, safety, and tolerability of these preparations and their role in menopausal management.