PT - JOURNAL ARTICLE AU - Michael Fleming AU - Marlon Mundt TI - Carbohydrate-Deficient Transferrin: Validity of a New Alcohol Biomarker in a Sample of Patients with Diabetes and Hypertension AID - 10.3122/jabfm.17.4.247 DP - 2004 Jul 01 TA - The Journal of the American Board of Family Practice PG - 247--255 VI - 17 IP - 4 4099 - http://www.jabfm.org/content/17/4/247.short 4100 - http://www.jabfm.org/content/17/4/247.full SO - J Am Board Fam Med2004 Jul 01; 17 AB - Objective: To test the reliability and validity of a new alcohol biomarker.Design: Cross-sectional with matched control. Alcohol use, symptoms of alcohol dependence, health status, current medications, carbohydrate-deficient transferrin (CDT) levels, and γ-glutamyl transferase levels were assessed. Validity of the %CDT test was estimated using a drinking cutoff of 90 or more drinks in the previous 30 days.Participants: Sample (n = 799) included 89 patients with type 2 diabetes, 299 patients with hypertension, 209 patients with hypertension and type 2 diabetes, and 202 matched control subjects with neither diabetes nor hypertension.Results: Three hundred ninety-six women and 403 men ages 30 to 60 participated in the study. Six percent (45 of 799) reported drinking more than 14 drinks per week, 2% (n = 17) met criteria for alcohol abuse, and 3% (n = 23) met DSM-IV criteria for dependence. The overall sensitivity of the %CDT test was 61% with a specificity of 85%. A receiver operating characteristic curve was used to determine that the best fit was for persons who reported >90 drinks per month and a CDT level >2.5% with an area under the curve of 0.83. Test-retest reliability (R) was 0.94.Conclusions: %CDT levels are useful in detecting and/or confirming high-risk drinking in patients being treated for type 2 diabetes and hypertension.