PT  - JOURNAL ARTICLE
AU  - Simmons, B. Brent
AU  - Folsom, Michelle A.
AU  - Bryden, Leslie A.
AU  - Studdiford, James S.
TI  - Angioedema After Local Trauma in a Patient on Angiotensin-Converting Enzyme Inhibitor Therapy
AID  - 10.3122/jabfm.2008.06.080103
DP  - 2008 Nov 01
TA  - The Journal of the American Board of Family Medicine
PG  - 577--579
VI  - 21
IP  - 6
4099  - http://www.jabfm.org/content/21/6/577.short
4100  - http://www.jabfm.org/content/21/6/577.full
SO  - J Am Board Fam Med2008 Nov 01; 21
AB  - Angioedema is a side effect that is often associated with the use of angiotensin-converting enzyme (ACE) inhibitor medications. These medications result in increased levels of circulating bradykinins. This case illustrates the result of a local traumatic event to the upper lip, presumably causing marked bradykinin release in a patient who was taking an ACE inhibitor. The local release of bradykinin from trauma, in addition to decreased bradykinin catabolism secondary to ACE inhibitor therapy, resulted in angioedema predominantly in the upper lip. The angioedema resolved with discontinuation of the ACE inhibitor.