RT Journal Article SR Electronic T1 Obesity: Effects on Cardiovascular Disease and its Diagnosis JF The Journal of the American Board of Family Medicine JO J Am Board Fam Med FD American Board of Family Medicine SP 562 OP 568 DO 10.3122/jabfm.2008.06.080080 VO 21 IS 6 A1 Boban Mathew A1 Lisa Francis A1 Attila Kayalar A1 Jesse Cone YR 2008 UL http://www.jabfm.org/content/21/6/562.abstract AB The higher prevalence of cardiovascular disease in obese individuals is indirectly mediated, to a large extent, by the increased frequency of various well known risk factors like hypertension, diabetes, and dyslipidemia, either individually or as part of the metabolic syndrome. However, there are several ways in which obesity directly affects the cardiovascular system; these will be discussed in detail. We also focus on various challenges posed by obesity in the performance and interpretation of cardiac investigations and how they can be addressed.