PT - JOURNAL ARTICLE AU - Ian M. Bennett AU - Andrew Coco AU - James C. Coyne AU - Alex J. Mitchell AU - James Nicholson AU - Ellen Johnson AU - Michael Horst AU - Stephen Ratcliffe TI - Efficiency of a Two-Item Pre-Screen to Reduce the Burden of Depression Screening in Pregnancy and Postpartum: An IMPLICIT Network Study AID - 10.3122/jabfm.2008.04.080048 DP - 2008 Jul 01 TA - The Journal of the American Board of Family Medicine PG - 317--325 VI - 21 IP - 4 4099 - http://www.jabfm.org/content/21/4/317.short 4100 - http://www.jabfm.org/content/21/4/317.full SO - J Am Board Fam Med2008 Jul 01; 21 AB - Objective: Systems for efficient case finding of women with major depression during pregnancy and postpartum are needed. Here we assess the diagnostic accuracy of a modified 2-item patient health questionnaire (PHQ-2) as a pre-screen in assessing depression.Methods: Cross-sectional assessments at 15 weeks' gestation (n = 414), 30 weeks' gestation (n = 334), and 6 to 16 weeks postpartum (n = 193) among women from a diverse set of races/ethnicities, participating in the IMPLICIT maternal care quality improvement network. The Edinburgh Postnatal Depression Scale score (≥13) was used as the criterion measure for the PHQ-2.Results: A positive 2-item screen had sensitivity of 93%, 82%, and 80% and specificity of 75%, 80%, and 86% for Edinburgh Postnatal Depression Scale score of ≥13 for assessment at 15 and 30 weeks gestational age and postpartum, respectively. The positive/negative predictive values for the PHQ-2 were 44/98, 24/91, and 30/98 for each time point, respectively. Areas under the receiver operating characteristic curve analysis suggested that 2-item assessments at each time point had approximately equal diagnostic validity.Conclusions: Two questions were efficient to rule out depression and reduced the need for further screening of approximately 60% to 80% of women, depending on the point in pregnancy or postpartum. A diagnostic interview follow-up of women screening positive is still required.