RT Journal Article
SR Electronic
T1 Masked Clozapine-induced Cardiomyopathy
JF The Journal of the American Board of Family Medicine
JO J Am Board Fam Med
FD American Board of Family Medicine
SP 70
OP 74
DO 10.3122/jabfm.2008.01.070091
VO 21
IS 1
A1 Pastor, Charles A.
A1 Mehta, Monica
YR 2008
UL http://www.jabfm.org/content/21/1/70.abstract
AB A 33-year-old Latin-American woman with a history of psychosis and mood disorder, but no cardiac history or risk factors, presented with heart failure after 6 weeks of clozapine and olanzapine therapy. Her presentation was ambiguous and further complicated by a highly suggestible nature, which delayed the proper diagnosis and treatment. After discontinuing the antipsychotic agents and completing an otherwise negative comprehensive work-up, her heart function significantly improved (left ventricular ejection fraction increased from 38% to 53%). A literature search showed that cardiomyopathy secondary to antipsychotics has been reported but remains poorly understood. This is the second documented case report of clozapine-induced cardiomyopathy in a Latin-American woman.