PT  - JOURNAL ARTICLE
AU  - Pastor, Charles A.
AU  - Mehta, Monica
TI  - Masked Clozapine-induced Cardiomyopathy
AID  - 10.3122/jabfm.2008.01.070091
DP  - 2008 Jan 01
TA  - The Journal of the American Board of Family Medicine
PG  - 70--74
VI  - 21
IP  - 1
4099  - http://www.jabfm.org/content/21/1/70.short
4100  - http://www.jabfm.org/content/21/1/70.full
SO  - J Am Board Fam Med2008 Jan 01; 21
AB  - A 33-year-old Latin-American woman with a history of psychosis and mood disorder, but no cardiac history or risk factors, presented with heart failure after 6 weeks of clozapine and olanzapine therapy. Her presentation was ambiguous and further complicated by a highly suggestible nature, which delayed the proper diagnosis and treatment. After discontinuing the antipsychotic agents and completing an otherwise negative comprehensive work-up, her heart function significantly improved (left ventricular ejection fraction increased from 38% to 53%). A literature search showed that cardiomyopathy secondary to antipsychotics has been reported but remains poorly understood. This is the second documented case report of clozapine-induced cardiomyopathy in a Latin-American woman.