RT Journal Article
SR Electronic
T1 For Atrial Fibrillation, DOACs Outperform Warfarin in Patients with Reduced Kidney Function
JF The Journal of the American Board of Family
                Medicine
JO J Am Board Fam Med
FD American Board of Family Medicine
SP jabfm.2024.240155R0
DO 10.3122/jabfm.2024.240155R0
A1 Powell, Robert A.
A1 Coulter, Jessica S.
A1 Hoffman, Ariel L.
A2 Brown, Carina
YR 2025
UL http://www.jabfm.org/content/early/2025/01/16/jabfm.2024.240155R0.abstract
AB At standard doses, direct oral anticoagulants (DOACs) were associated with a reduced risk of systemic embolism and intracranial hemorrhage (ICH) when compared with warfarin, with a greater derived benefit at lower creatinine clearance (CrCl-down to 25 mL/min). Lower doses of DOACs were associated with increased overall mortality without a significant decrease in ICH and incident bleeding when compared with standard dose DOACs and warfarin, across all CrCl down to 25 mL/min.1