PT  - JOURNAL ARTICLE
AU  - Powell, Robert A.
AU  - Coulter, Jessica S.
AU  - Hoffman, Ariel L.
ED  - Brown, Carina
TI  - For Atrial Fibrillation, DOACs Outperform Warfarin in Patients with Reduced Kidney Function
AID  - 10.3122/jabfm.2024.240155R0
DP  - 2025 Jan 17
TA  - The Journal of the American Board of Family
                Medicine
PG  - jabfm.2024.240155R0
4099  - http://www.jabfm.org/content/early/2025/01/16/jabfm.2024.240155R0.short
4100  - http://www.jabfm.org/content/early/2025/01/16/jabfm.2024.240155R0.full
AB  - At standard doses, direct oral anticoagulants (DOACs) were associated with a reduced risk of systemic embolism and intracranial hemorrhage (ICH) when compared with warfarin, with a greater derived benefit at lower creatinine clearance (CrCl-down to 25 mL/min). Lower doses of DOACs were associated with increased overall mortality without a significant decrease in ICH and incident bleeding when compared with standard dose DOACs and warfarin, across all CrCl down to 25 mL/min.1