PT - JOURNAL ARTICLE AU - Close, Elizabeth AU - Jones, Alexander AU - Noggle, William ED - Crawford, Paul TI - Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention AID - 10.3122/jabfm.2024.240056R0 DP - 2025 Jan 17 TA - The Journal of the American Board of Family Medicine PG - jabfm.2024.240056R0 4099 - http://www.jabfm.org/content/early/2025/01/16/jabfm.2024.240056R0.short 4100 - http://www.jabfm.org/content/early/2025/01/16/jabfm.2024.240056R0.full AB - Consider prescribing doxycycline as prophylaxis for bacterial sexually transmitted infections (STIs) in certain clinical scenarios. New data suggests that a one-time dose of 200 mg doxycycline taken within 72 hours of an unprotected sexual encounter may reduce transmission of syphilis, gonorrhea and chlamydia by a combined two thirds in a high-risk population.