TY - JOUR T1 - First-line pharmacotherapy for tobacco use and dependence. JF - The Journal of the American Board of Family Practice JO - J Am Board Fam Med SP - 489 LP - 497 VL - 15 IS - 6 AU - Steve A Watts AU - Sara L Noble AU - Patrick O Smith AU - Marilyn Disco Y1 - 2002/11/01 UR - http://www.jabfm.org/content/15/6/489.abstract N2 - First-line pharmacotherapies for tobacco use and dependence (namely, nicotine patch, nicotine gum, nicotine inhaler, nicotine nasal spray, and sustained-release bupropion) are safe and have been empirically determined to be efficacious and should always be considered part of a tobacco treatment intervention program unless contraindicated. Studies published subsequent to the literature synthesized in TTUD support previously determined efficacy of first-line pharmacologic medications for treatment of tobacco use and dependence. Further studies will be necessary to define clearly the efficacy and relative safety of combination treatments. ER -