PT - JOURNAL ARTICLE AU - Steve A Watts AU - Sara L Noble AU - Patrick O Smith AU - Marilyn Disco TI - First-line pharmacotherapy for tobacco use and dependence. DP - 2002 Nov 01 TA - The Journal of the American Board of Family Practice PG - 489--497 VI - 15 IP - 6 4099 - http://www.jabfm.org/content/15/6/489.short 4100 - http://www.jabfm.org/content/15/6/489.full SO - J Am Board Fam Med2002 Nov 01; 15 AB - First-line pharmacotherapies for tobacco use and dependence (namely, nicotine patch, nicotine gum, nicotine inhaler, nicotine nasal spray, and sustained-release bupropion) are safe and have been empirically determined to be efficacious and should always be considered part of a tobacco treatment intervention program unless contraindicated. Studies published subsequent to the literature synthesized in TTUD support previously determined efficacy of first-line pharmacologic medications for treatment of tobacco use and dependence. Further studies will be necessary to define clearly the efficacy and relative safety of combination treatments.