RT Journal Article SR Electronic T1 A Case of Extra-Articular Coccidioidomycosis in the Knee of a Healthy Patient JF The Journal of the American Board of Family Medicine JO J Am Board Fam Med FD American Board of Family Medicine SP jabfm.2022.220234R2 DO 10.3122/jabfm.2022.220234R2 A1 Martinez, Alaina A1 McClaskey, David YR 2023 UL http://www.jabfm.org/content/early/2023/02/16/jabfm.2022.220234R2.abstract AB Coccidioidomycosis is a fungal infection endemic to the Southwestern United States. Extrapulmonary Coccidioides immitis infections are uncommon and occur more frequently in immunocompromised individuals. There is often a delay in diagnosis and treatment due to the chronic, indolent nature of these infections. The clinical presentation is often nonspecific, and includes joint pain, erythema, or localized swelling. Therefore, these infections may only be identified after initial treatment failure and further workup is pursued. The majority of reported cases of coccidioidomycosis involving the knee have had intra-articular involvement or extension. This report describes a rare case of peri-articular Coccidioides immitis abscess of the knee that does not communicate with the joint in a healthy patient. This case illustrates the low threshold needed for additional testing, such as fluid or tissue sampling of joint-related fluid collections if the etiology is unclear. A high index of suspicion is prudent to avoid diagnostic delay, particularly for individuals who either reside in or travel to endemic areas.