RT Journal Article
SR Electronic
T1 Transient Hyperthyroidism of Hyperemesis Gravidarum: A Sheep in Wolfs Clothing
JF The Journal of the American Board of Family
                Practice
JO J Am Board Fam Med
FD American Board of Family Medicine
SP 35
OP 38
DO 10.3122/jabfm.13.1.35
VO 13
IS 1
A1 Timothy J. Caffrey
YR 2000
UL http://www.jabfm.org/content/13/1/35.abstract
AB Background: Transient hyperthyroidism of hyperemesis gravidarum (THHG) is a self-limiting hyperthyroidism occurring in the context of hyperemesis gravidarum. Methods: A literature search of MEDLINE was undertaken, and a case report of a woman with THHG in pregnancy is described. Results and Conclusions: Because thyroid function tests cannot distinguish Graves disease from THHG, the diagnosis of THHG rests largely on the concurrent development of hyperemesis and hyperthyroidism and the absence of signs and symptoms of hyperthyroidism before and during pregnancy. THHG might be responsible for 40% to 70% of thyroid function abnormalities in pregnancy. Both the thyroid function abnormalities and hyperemesis are related to elevated levels of human chorionic gonadotropin. THHG resolves by 18 weeks of pregnancy without sequelae. No treatment is required. Diagnosis of THHG by the primary care provider can prevent unnecessary treatment or referral for specialty care.