RT Journal Article SR Electronic T1 The Association Between Social Isolation and Memory Loss Among Older Adults JF The Journal of the American Board of Family Medicine JO J Am Board Fam Med FD American Board of Family Medicine SP jabfm.2022.AP.210497 DO 10.3122/jabfm.2022.AP.210497 A1 David M. Mosen A1 Matthew P. Banegas A1 Erin M. Keast A1 Briar L. Ertz-Berger YR 2022 UL http://www.jabfm.org/content/early/2022/09/15/jabfm.2022.AP.210497.abstract AB Introduction: Social isolation among older individuals is associated with poor health outcomes. However, less is known about the association between social isolation and memory loss, specifically among Medicare enrollees in large, integrated health care systems.Methods: We conducted a cross-sectional, observational study. From a cohort of 46,240 Medicare members aged 65 years and older at Kaiser Permanente Northwest (KPNW) who completed a health questionnaire, we compared self-reported memory loss of those who reported feeling lonely or socially isolated and those who did not, adjusting for demographic factors, health conditions, and use of health services in the 12 months before the survey.Results: Patients who reported sometimes experiencing social isolation were more likely than those who rarely or never experienced social isolation to report memory loss in both unadjusted (odds ratio [ORsometimes]: 2.56, 95% CI= 2.42-2.70, P = 0.0076) and adjusted (ORsometimes: 2.45, 95% CI= 2.32-2.60, P = .0298) logistic regression models. Similarly, those who reported social isolation often or always were more likely to report memory loss than those who reported rarely or never experiencing isolation in both unadjusted (ORoften/always: 5.50, 95% CI = 5.06-5.99, P < .0001) and adjusted logistic regression models (ORoften/always: 5.20, 95% CI = 4.75-5.68, P < .0001).Conclusions: The strong association between social isolation and memory loss suggest the need to develop interventions to reduce isolation and to evaluate their effects on potential future memory loss.