RT Journal Article
SR Electronic
T1 Are Amphetamines Associated with Adverse Cardiovascular Events Among Elderly Individuals?
JF The Journal of the American Board of Family
                Medicine
JO J Am Board Fam Med
FD American Board of Family Medicine
SP 1074
OP 1081
DO 10.3122/jabfm.2021.06.210228
VO 34
IS 6
A1 James R. Latronica
A1 Taylor J. Clegg
A1 Wen-Jan Tuan
A1 Curtis Bone
YR 2021
UL http://www.jabfm.org/content/34/6/1074.abstract
AB Background: Prescription amphetamines are the most common pharmacological treatment for attention deficit hyperactivity disorder (ADHD) and use among older age groups is increasing. The purpose of this study is to assess the risk of adverse cardiovascular events among individuals older than 65 years.Methods: We conducted a retrospective matched cohort study using TriNetX database with propensity score matching (PSM) to assess the odds of a cardiovascular event among individuals with ADHD exposed to amphetamine compared with individuals with ADHD who were not exposed to this medication. During the index period of January 1, 2018, through December 31, 2020, 13,233 individuals older than 65 years (mean age = 69 years) met the study criteria.Results: The cohort exposed to amphetamine had increased blood pressure and increased odds of cardiovascular events (odds ratio [OR], 6.16; absolute risk difference = 3.31%) compared with the control group.Conclusions: Amphetamines have clear safety data in younger age cohorts; however, this safety data may not generalize to older populations. Additional research is warranted to clarify further exposure and subpopulation-level risk factors associated with adverse cardiovascular events among older patients.