RT Journal Article
SR Electronic
T1 Human Papillomavirus-Associated Head and Neck Cancer
JF The Journal of the American Board of Family
                Medicine
JO J Am Board Fam Med
FD American Board of Family Medicine
SP 832
OP 837
DO 10.3122/jabfm.2021.04.200588
VO 34
IS 4
A1 Juan C. Nogues
A1 Scott Fassas
A1 Collin Mulcahy
A1 Philip E. Zapanta
YR 2021
UL http://www.jabfm.org/content/34/4/832.abstract
AB Oropharyngeal squamous cell carcinoma (OPSCC) has historically been attributable to tobacco and alcohol exposure and saw a decline in incidence after societal norms shifted away from smoking. In recent decades, this disease has had a re-emergence due to human papillomavirus (HPV) infection, now surpassing cervical cancer as the number 1 cause of HPV-related cancer in the United States. HPV-positive OPSCC differs from HPV-negative disease in epidemiology, prognosis, treatment, and prevention. Additionally, there is a deficit in awareness of the causal relationship between HPV and OPSCC. This, coupled with low vaccination rates, puts primary care providers in a unique position to play a vital role in prevention and early diagnosis. In this review, we highlight the epidemiology, screening, patient presentation, diagnosis, prognosis, and prevention of HPV-positive OPSCC, with a focus on the primary care provider's role.