PT - JOURNAL ARTICLE AU - Stephen J. Titus AU - Robert N. Suter AU - Anh T. Hoang AU - Paul A. Figel TI - Expanding the Differential During the COVID-19 Pandemic: Fatal West Nile Virus Neuroinvasive Disease AID - 10.3122/jabfm.2021.03.200630 DP - 2021 May 01 TA - The Journal of the American Board of Family Medicine PG - 661--662 VI - 34 IP - 3 4099 - http://www.jabfm.org/content/34/3/661.short 4100 - http://www.jabfm.org/content/34/3/661.full SO - J Am Board Fam Med2021 May 01; 34 AB - The ever-evolving pandemic of Coronavirus disease 2019 (COVID-19) has the potential to drown out other viruses continuing to infect communities. To highlight this, we present 2 cases of fatal West Nile virus neuroinvasive disease that occurred within 2 weeks of each other. Since the first positive case of West Nile virus in the United States, there have been 2 epidemics in the past 2 decades, most often occurring in regions of North Texas and Southern California, which have been areas of high-incidence for COVID-19. It is important for the health care provider to recognize diagnostic biases and maintain broad differentials for the patient presenting with fever and other symptoms associated with COVID-19.