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Research ArticleResearch Letter

Long COVID and Days of Work Missed Due to Illness or Injury by Adults in the United States, 2022

Rachel Liu-Galvin, Frank A. Orlando, Tamkeen Khan, Gregory D. Wozniak and Arch G. Mainous
The Journal of the American Board of Family Medicine August 2025, DOI: https://doi.org/10.3122/jabfm.2024.240367R1
Rachel Liu-Galvin
From the Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL (RLG, AGM); Department of Community Health and Family Medicine, University of Florida, Gainesville, FL (FAO, AGM); American Medical Association, Chicago, IL (TK, GDW).
MBChB
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Frank A. Orlando
From the Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL (RLG, AGM); Department of Community Health and Family Medicine, University of Florida, Gainesville, FL (FAO, AGM); American Medical Association, Chicago, IL (TK, GDW).
MD
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Tamkeen Khan
From the Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL (RLG, AGM); Department of Community Health and Family Medicine, University of Florida, Gainesville, FL (FAO, AGM); American Medical Association, Chicago, IL (TK, GDW).
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Gregory D. Wozniak
From the Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL (RLG, AGM); Department of Community Health and Family Medicine, University of Florida, Gainesville, FL (FAO, AGM); American Medical Association, Chicago, IL (TK, GDW).
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Arch G. Mainous III
From the Department of Health Services Research, Management, and Policy, University of Florida, Gainesville, FL (RLG, AGM); Department of Community Health and Family Medicine, University of Florida, Gainesville, FL (FAO, AGM); American Medical Association, Chicago, IL (TK, GDW).
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Article Figures & Data

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    Table 1.

    Characteristics of the Population Overall and Stratified by COVID-19 and Long COVID History

    CharacteristicOverallNever Had COVID-19Had COVID-19 Without Long COVIDHad Long COVIDP value
    Weighted FrequencyWeighted % (SE)Weighted FrequencyWeighted % (SE)Weighted FrequencyWeighted % (SE)Weighted FrequencyWeighted % (SE)
    Total population 125,151,40210053,694,10042.9 (0.72)62,099,28149.6 (0.74)9,358,0217.5 (0.37) 
    Age (years)0.0215
     18 to 4468,415,22354.7 (0.87)28,495,42053.1 (1.17)35,219,05356.7 (1.25)4,700,75050.2 (2.84)
     ≥4556,736,17945.3 (0.87)25,198,68046.9 (1.17)26,880,22843.3 (1.25)4,657,27149.8 (2.84)
    Sex<0.0001
     Male70,978,14856.7 (0.56)31,809,504 59.2 (0.95)34,987,964 56.3 (0.82)4,180,680 44.7 (2.60)
     Female54,173,25443.3 (0.56)21,884,596 40.8 (0.95)27,111,317 43.7 (0.82)5,177,341 55.3 (2.60)
    Race<0.0001
     Non-Hispanic White73,854,29159.0 (1.21)29,023,17654.1 (1.50)38,350,40561.8 (1.33)6,480,71069.3 (2.35)
     Other51,297,11141.0 (1.21)24,670,92445.9 (1.50)23,748,87638.2 (1.33)2,877,31130.7 (2.35)
    Education<0.0001
     High school diploma or lower56,340,39245.5 (1.03)26,879,30050.7 (1.36)25,063,45840.6 (1.23)4,397,63447.6 (3.01)
     College degree67,607,26254.5 (1.03)26,150,79449.3 (1.36)36,613,47059.4 (1.23)4,842,99752.4 (3.01)
    Census region0.0021
     Northeast21,108,93716.9 (1.30)8,089,02715.1 (1.41)11,363,19318.3 (1.49)1,656,71717.7 (2.12)
     Midwest26,104,15120.9 (1.60)10,732,98120.0 (1.71)13,048,86721.0 (1.66)2,322,30324.8 (3.00)
     South48,350,37138.6 (1.87)22,353,95141.6 (1.98)22,608,33736.4 (2.03)3,388,08236.2 (3.27)
     West29,587,94323.6 (1.56)12,518,14123.3 (1.73)15,078,88324.3 (1.69)1,990,91921.3 (2.12)
    Marital status<0.0001
     Married70,125,97856.0 (0.88)27,407,94351.0 (1.21)37,464,37160.3 (1.23)5,253,66456.1 (2.57)
     Not married55,025,42444.0 (0.88)26,286,15849.0 (1.21)24,634,90939.7 (1.23)4,104,35743.9 (2.57)
    Has a usual care provider<0.0001
     Yes76,882,82064.2 (0.87)29,791,06758.5 (1.41)40,580,45367.8 (1.06)6,511,30072.5 (2.62)
     No42,857,93835.8 (0.87)21,153,05641.5 (1.41)19,235,20832.2 (1.06)2,469,67427.5 (2.62)
    Paid sick leave<0.0001
     Yes87,342,66080.3 (0.67)35,235,64576.6 (1.03)45,559,21583.5 (0.79)6,547,80179.2 (2.41)
     No21,492,40819.7 (0.67)10,759,00623.4 (1.03)9,009,02216.5 (0.79)1,724,38120.8 (2.41)
    Ever had a COVID-19 vaccine0.2259
     Yes103,148,66383.1 (0.75)43,707,26282.3 (0.94)51,925,98684.1 (0.97)7,515,41581.6 (2.31)
     No20,908,68716.9 (0.75)9,421,62517.7 (0.94)9,796,64715.9 (0.97)1,690,41518.4 (2.31)
    Current cigarette smoker<0.0001
     Yes14,426,61111.6 (0.54)7,606,26114.3 (0.81)5,574,3959.0 (0.66)1,245,95613.5 (1.76)
     No109,735,93388.4 (0.5)45,529,82585.7 (0.81)56,198,89691.0 (0.66)8,007,21386.5 (1.76)
    Previous diagnosis of asthma, chronic bronchitis (past 12 months), or emphysema<0.0001
     Yes17,588,39514.1 (0.50)6,639,72512.4 (0.66)8,801,06114.2 (0.69)2,147,61023.0 (2.23)
     No107,031,47685.9 (0.50)46,768,07487.6 (0.66)53,073,15085.8 (0.69)7,190,25277.0 (2.23)
    Previous diagnosis of diabetes0.1856
     Yes9,246,6337.4 (0.42)4,033,9577.5 (0.51)4,326,6167.0 (0.58)886,0609.5 (1.51)
     No115,867,65492.6 (0.42)49,637,62992.5 (0.51)57,758,06493.0 (0.58)8,471,96190.5 (1.51)
    Previous diagnosis of hypertension0.0008
     Yes29,962,98224.0 (0.63)12,658,10823.6 (0.83)14,338,82623.1 (0.96)2,966,04831.7 (2.22)
     No95,022,28876.0 (0.63)40,950,64076.4 (0.83)47,679,67576.9 (0.96)6,391,97368.3 (2.22)
    • Abbreviation: SE, standard error.

    • View popup
    Table 2.

    Number of Days of Work Missed Due to Illness or Injury in 2022, Stratified by COVID-19 and Long COVID History

    VariableGroup 1: Never Had COVID-19Group 2:  Had COVID-19 Wthout Long COVIDGroup 3:Had Long COVIDP valuePost-Hoc Test (Tukey-Kramer)
    Weighted Mean (SE)Weighted Mean (SE)Weighted Mean (SE)Group ComparisonDifference, Weighted Mean (SE)Adjusted 95% Confidence IntervalsAdjusted P value
    Number of days of work missed due to illness or injury in 2022 3.12 (0.19)5.20 (0.22)8.44 (0.60)<0.00012 versus 12.08 (0.29)(1.39, 2.76)<0.0001
    3 versus 15.32 (0.72)(3.62, 7.02)<0.0001
    2 versus 3−3.24 (0.71)(−4.92, −1.55)<0.0001
    • Abbreviation: SE, standard error.

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The Journal of the American Board of Family   Medicine: 38 (6)
The Journal of the American Board of Family Medicine
Vol. 38, Issue 6
November-December 2025
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Long COVID and Days of Work Missed Due to Illness or Injury by Adults in the United States, 2022
Rachel Liu-Galvin, Frank A. Orlando, Tamkeen Khan, Gregory D. Wozniak, Arch G. Mainous
The Journal of the American Board of Family Medicine Aug 2025, DOI: 10.3122/jabfm.2024.240367R1

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Long COVID and Days of Work Missed Due to Illness or Injury by Adults in the United States, 2022
Rachel Liu-Galvin, Frank A. Orlando, Tamkeen Khan, Gregory D. Wozniak, Arch G. Mainous
The Journal of the American Board of Family Medicine Aug 2025, DOI: 10.3122/jabfm.2024.240367R1
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