Skip to main content

Main menu

  • HOME
  • ARTICLES
    • Current Issue
    • Archives
    • Special Collections
    • Abstracts In Press
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
  • CLASSIFIEDS
  • Other Publications
    • abfm

User menu

Search

  • Advanced search
American Board of Family Medicine
  • Other Publications
    • abfm
American Board of Family Medicine

American Board of Family Medicine

Advanced Search

  • HOME
  • ARTICLES
    • Current Issue
    • Archives
    • Special Collections
    • Abstracts In Press
  • INFO FOR
    • Authors
    • Reviewers
    • Call For Papers
    • Subscribers
    • Advertisers
  • SUBMIT
    • Manuscript
    • Peer Review
  • ABOUT
    • The JABFM
    • The Editing Fellowship
    • Editorial Board
    • Indexing
  • CLASSIFIEDS
  • JABFM on Bluesky
  • JABFM On Facebook
  • JABFM On Twitter
  • JABFM On YouTube
Research ArticlePriority Updates from the Research Literature (PURLs)

Esketamine: A Possible Adjunctive Therapy for Treatment Resistant Depression

Annie Huang, Jennifer L. Fernandez Vasquez and Catherine A. Yeager
The Journal of the American Board of Family Medicine November 2025, 38 (6) 1120-1122; DOI: https://doi.org/10.3122/jabfm.2025.250369R0
Annie Huang
From the DD Eisenhower Army Medical Center Family Medicine Residency, Augusta, GA (AH, JLFV, CAY).
DO
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer L. Fernandez Vasquez
From the DD Eisenhower Army Medical Center Family Medicine Residency, Augusta, GA (AH, JLFV, CAY).
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Catherine A. Yeager
From the DD Eisenhower Army Medical Center Family Medicine Residency, Augusta, GA (AH, JLFV, CAY).
PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • References
  • Info & Metrics
  • PDF
Loading

References

  1. 1.↵
    1. Reif A,
    2. Bitter I,
    3. Buyze J
    , ESCAPE-TRD Investigatorset al. Esketamine nasal spray versus quetiapine for treatment-resistant depression. N Engl J Med 2023;389:1298–309.
    OpenUrlCrossRefPubMed
  2. 2.↵
    World Health Organization. Depression and other common mental disorders: global health estimates. Geneva: World Health Organization; 2017. License: CC-BY-NC-SA 3.0 IGO.
  3. 3.↵
    1. Gaynes BN,
    2. Lux L,
    3. Gartlehner G,
    4. et al
    . Defining treatment-resistant depression. Depress Anxiety 2020;37:134–45.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Li CT
    . Overview of treatment-resistant depression. Prog Brain Res 2023;278:1–23.1.
    OpenUrlPubMed
  5. 5.↵
    1. Little A
    . Treatment-resistant depression. Am Fam Physician 2009;80:167–72.
    OpenUrlPubMedWeb of Science
  6. 6.↵
    1. Greenberg PE,
    2. Fournier AA,
    3. Sisitsky T,
    4. Pike CT,
    5. Kessler RC
    . The economic burden of adults with major depressive disorder in the United States (2005 and 2010). J Clin Psychiatry 2015;76:155–62.
    OpenUrlCrossRefPubMed
  7. 7.
    Depression in adults: treatment and management. London: National Institute for Health and Care Excellence (NICE); June 29, 2022.
  8. 8.↵
    1. Ruberto VL,
    2. Jha MK,
    3. Murrough JW
    . Pharmacological treatments for patients with treatment-resistant depression. Pharmaceuticals (Basel) 2020;13:116.
    OpenUrlPubMed
  9. 9.↵
    1. Smith P,
    2. Castelli G
    . The Priority Updates from the Research Literature (PURLs) Methodology. J Am Board Fam Med 2024;37:799–802.
    OpenUrlFREE Full Text
PreviousNext
Back to top

In this issue

The Journal of the American Board of Family   Medicine: 38 (6)
The Journal of the American Board of Family Medicine
Vol. 38, Issue 6
November-December 2025
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on American Board of Family Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Esketamine: A Possible Adjunctive Therapy for Treatment Resistant Depression
(Your Name) has sent you a message from American Board of Family Medicine
(Your Name) thought you would like to see the American Board of Family Medicine web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Esketamine: A Possible Adjunctive Therapy for Treatment Resistant Depression
Annie Huang, Jennifer L. Fernandez Vasquez, Catherine A. Yeager
The Journal of the American Board of Family Medicine Nov 2025, 38 (6) 1120-1122; DOI: 10.3122/jabfm.2025.250369R0

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Esketamine: A Possible Adjunctive Therapy for Treatment Resistant Depression
Annie Huang, Jennifer L. Fernandez Vasquez, Catherine A. Yeager
The Journal of the American Board of Family Medicine Nov 2025, 38 (6) 1120-1122; DOI: 10.3122/jabfm.2025.250369R0
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Strength of Recommendation
    • Illustrative Case
    • Clinical Context
    • Methods
    • Study Summary
    • What Is New
    • Caveats
    • Challenges to Implementation
    • Notes
    • References
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Are Single-Pill Antihypertensive Combinations Superior to Multi-Pill Regimens at Reducing All-Cause Mortality and Cardiovascular Events?
  • Preventing Early Onset GBS Neonatal Sepsis – Are Second Line Intrapartum Antibiotics Equivalent to No Antibiotics at All?
Show more Priority Updates from the Research Literature (PURLs)

Similar Articles

Keywords

  • Depression
  • Esketamine

Navigate

  • Home
  • Current Issue
  • Past Issues

Authors & Reviewers

  • Info For Authors
  • Info For Reviewers
  • Submit A Manuscript/Review

Other Services

  • Get Email Alerts
  • Classifieds
  • Reprints and Permissions

Other Resources

  • Forms
  • Contact Us
  • ABFM News

© 2026 American Board of Family Medicine

Powered by HighWire