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Research ArticleOriginal Research

Evaluation of Asymptomatic Fasting Hypoglycemia in Outpatients Without Diabetes

Tomás González-Vidal, Óscar Lado-Baleato, Carmen Fernández-Merino, Juan Sánchez-Castro, Manuela Alonso-Sampedro, Jessica Ares, Elías Delgado, Edelmiro Menéndez-Torre and Francisco Gude
The Journal of the American Board of Family Medicine May 2025, 38 (3) 411-422; DOI: https://doi.org/10.3122/jabfm.2024.240274R1
Tomás González-Vidal
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD
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Óscar Lado-Baleato
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
BSc, PhD
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Carmen Fernández-Merino
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD, PhD
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Juan Sánchez-Castro
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD
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Manuela Alonso-Sampedro
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
BSc, PhD
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Jessica Ares
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD, PhD
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Elías Delgado
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD, PhD
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Edelmiro Menéndez-Torre
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD, PhD
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Francisco Gude
From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
MD, PhD
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Article Information

vol. 38 no. 3 411-422
DOI 
https://doi.org/10.3122/jabfm.2024.240274R1
PubMed 
40789619

Published By 
The Journal of the American Board of Family Medicine
Print ISSN 
1557-2625
Online ISSN 
1558-7118
History 
  • Received for publication July 20, 2024
  • Revision received November 18, 2024
  • Accepted for publication December 11, 2025
  • Published online September 15, 2025.

Copyright & Usage 
© 2025 Copyright by the American Board of Family Medicine.

Author Information

  1. Tomás González-Vidal, MD,
  2. Óscar Lado-Baleato, BSc, PhD,
  3. Carmen Fernández-Merino, MD, PhD,
  4. Juan Sánchez-Castro, MD,
  5. Manuela Alonso-Sampedro, BSc, PhD,
  6. Jessica Ares, MD, PhD,
  7. Elías Delgado, MD, PhD,
  8. Edelmiro Menéndez-Torre, MD, PhD and
  9. Francisco Gude, MD, PhD
  1. From the Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Spain (TGV, JA, ED, EMT); Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain (TGV, JA, ED, EMT); Department of Medicine, University of Oviedo, Spain (TGV, JA, ED, EMT); Research Methods Group (RESMET), Health Research Institute of Santiago de Compostela (IDIS, ÓLB, FG); Santiago de Compostela, Spain (OLB, CFM, JSC, MAS); ISCIII Support Platforms for Clinical Research, Health Research Institute of Santiago de Compostela, Spain (OLB); A Estrada Primary Care Center, A Estrada, Spain (CFM, JSC); Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPSISCIII), Santiago de Compostela, Spain (CFM, JSC, MAS, FG); Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain (ED, EMT); Department of Psychiatry, Radiology, Public Health, Nursing and Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain (CFM, FG); and Concepción Arenal Primary Care Center, Santiago de Compostela, Spain (FG).
  1. Corresponding author: Tomás González-Vidal, MD, Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Avenida de Roma s/n, 33011, Oviedo, Spain (E-mail: uo302763{at}uniovi.es).
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The Journal of the American Board of Family Medicine: 38 (3)
The Journal of the American Board of Family Medicine
Vol. 38, Issue 3
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Evaluation of Asymptomatic Fasting Hypoglycemia in Outpatients Without Diabetes
Tomás González-Vidal, Óscar Lado-Baleato, Carmen Fernández-Merino, Juan Sánchez-Castro, Manuela Alonso-Sampedro, Jessica Ares, Elías Delgado, Edelmiro Menéndez-Torre, Francisco Gude
The Journal of the American Board of Family Medicine May 2025, 38 (3) 411-422; DOI: 10.3122/jabfm.2024.240274R1

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Evaluation of Asymptomatic Fasting Hypoglycemia in Outpatients Without Diabetes
Tomás González-Vidal, Óscar Lado-Baleato, Carmen Fernández-Merino, Juan Sánchez-Castro, Manuela Alonso-Sampedro, Jessica Ares, Elías Delgado, Edelmiro Menéndez-Torre, Francisco Gude
The Journal of the American Board of Family Medicine May 2025, 38 (3) 411-422; DOI: 10.3122/jabfm.2024.240274R1
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Keywords

  • Asymptomatic Conditions
  • Continuous Glucose Monitoring
  • Endocrinology
  • Hypoglycemia
  • Primary Health Care

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