Review ArticleClinical Review

Olfactory Loss and Beyond: A Practical Review of Chemosensory Dysfunction

Lauren E. Claus, Evelyn M. Leland, Katherine Y. Tai, Rodney J. Schlosser, Vidyulata Kamath, Andrew P. Lane and Nicholas R. Rowan
The Journal of the American Board of Family Medicine March 2022, 35 (2) 406-419; DOI: https://doi.org/10.3122/jabfm.2022.02.210373

References

  1. 1.↵
    1. Rebholz H,
    2. Braun RJ,
    3. Ladage D,
    4. Knoll W,
    5. Kleber C,
    6. Hassel AW
    . Loss of olfactory function—early indicator for COVID-19, other viral infections and neurodegenerative disorders. Front Neurol 2020;11:569333.
    OpenUrl
  2. 2.↵
    1. Boesveldt S,
    2. Postma EM,
    3. Boak D,
    4. et al
    . Anosmia–a clinical review. Chem Senses 2017;42:513–23.
    OpenUrlPubMed
  3. 3.↵
    1. Croy I,
    2. Nordin S,
    3. Hummel T
    . Olfactory disorders and quality of life–an updated review. Chem Senses 2014;39:185–94.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Doty RL
    . Age-related deficits in taste and smell. Otolaryngol Clin North Am 2018;51:815–25.
    OpenUrl
  5. 5.↵
    1. Zufall F,
    2. Munger SD
    1. Slack JP
    . Molecular pharmacology of chemesthesis. In: Zufall F, Munger SD, eds. Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli. 2016:375–91: Academic Press.
  6. 6.↵
    1. Meiselman HL
    1. Duffy VB,
    2. Hayes JE
    . Biological basis and functional assessment of oral sensation. In: Meiselman HL, ed. Handbook of Eating and Drinking. Springer; 2020:1–25.
  7. 7.↵
    1. Tremblay C,
    2. Frasnelli J
    . Olfactory and trigeminal systems interact in the periphery. Chem Senses 2018;43:611–6.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Hoffman HJ,
    2. Rawal S,
    3. Li CM,
    4. Duffy VB
    . New chemosensory component in the U.S. National Health and Nutrition Examination Survey (NHANES): first-year results for measured olfactory dysfunction. Rev Endocr Metab Disord 2016;17:221–40.
    OpenUrlPubMed
  9. 9.↵
    1. Ekstrom I,
    2. Sjolund S,
    3. Nordin S,
    4. et al
    . Smell loss predicts mortality risk regardless of dementia conversion. J Am Geriatr Soc 2017;65:1238–43.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Bernstein IA,
    2. Roxbury CR,
    3. Lin SY,
    4. Rowan NR
    . The association of frailty with olfactory and gustatory dysfunction in older adults: a nationally representative sample. Int Forum Allergy Rhinol 2021;11:866–76.
    OpenUrl
  11. 11.↵
    1. Choi JS,
    2. Jang SS,
    3. Kim J,
    4. Hur K,
    5. Ference E,
    6. Wrobel B
    . Association between olfactory dysfunction and mortality in US adults. JAMA Otolaryngol Head Neck Surg 2021;147:49–55.
    OpenUrlCrossRef
  12. 12.↵
    1. Blankenship ML,
    2. Grigorova M,
    3. Katz DB,
    4. Maier JX
    . Retronasal odor perception requires taste cortex, but orthonasal does not. Curr Biol 2019;29:62–9 e3.
    OpenUrl
  13. 13.↵
    1. Pinna F D R,
    2. Ctenas B,
    3. Weber R,
    4. Saldiva PH,
    5. Voegels RL
    . Olfactory neuroepithelium in the superior and middle turbinates: which is the optimal biopsy site? Int Arch Otorhinolaryngol 2013;17:131–8.
    OpenUrl
  14. 14.↵
    1. Morrison EE,
    2. Costanzo RM
    . Morphology of olfactory epithelium in humans and other vertebrates. Microsc Res Tech 1992;23:49–61.
    OpenUrlCrossRefPubMedWeb of Science
  15. 15.↵
    1. Goncalves S,
    2. Goldstein BJ
    . Pathophysiology of olfactory disorders and potential treatment strategies. Curr Otorhinolaryngol Rep 2016;4:115–21.
    OpenUrlCrossRef
  16. 16.↵
    1. Liu G,
    2. Zong G,
    3. Doty RL,
    4. Sun Q
    . Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study. BMJ Open 2016;6:e013246.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Dong J,
    2. Pinto JM,
    3. Guo X,
    4. et al
    . The prevalence of anosmia and associated factors among U.S. Black and White older adults. J Gerontol A Biol Sci Med Sci 2017;72:1080–6.
    OpenUrlPubMed
  18. 18.
    1. Pinto JM,
    2. Wroblewski KE,
    3. Kern DW,
    4. Schumm LP,
    5. McClintock MK
    . The rate of age-related olfactory decline among the general population of older U.S. adults. GERONA 2015;70:1435–41.
    OpenUrl
  19. 19.↵
    1. Yang J,
    2. Pinto JM
    . The Epidemiology of Olfactory Disorders. Curr Otorhinolaryngol Rep 2016;4:130–41.
    OpenUrlCrossRef
  20. 20.↵
    1. Murphy C,
    2. Schubert CR,
    3. Cruickshanks KJ,
    4. Klein BE,
    5. Klein R,
    6. Nondahl DM
    . Prevalence of olfactory impairment in older adults. JAMA 2002;288:2307–12.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.
    1. Devanand DP,
    2. Lee S,
    3. Manly J,
    4. et al
    . Olfactory identification deficits and increased mortality in the community. Ann Neurol 2015;78:401–11.
    OpenUrlCrossRefPubMed
  22. 22.
    1. Kern DW,
    2. Wroblewski KE,
    3. Schumm LP,
    4. Pinto JM,
    5. Chen RC,
    6. McClintock MK
    . Olfactory function in Wave 2 of the National Social Life, Health, and Aging Project. J Gerontol B Psychol Sci Soc Sci 2014;69:S134–43.
    OpenUrlCrossRefPubMed
  23. 23.
    1. Ross GW,
    2. Petrovitch H,
    3. Abbott RD,
    4. et al
    . Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 2008;63:167–73.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.
    1. Schlosser RJ,
    2. Desiato VM,
    3. Storck KA,
    4. et al
    . A community-based study on the prevalence of olfactory dysfunction. Am J Rhinol Allergy 2020;34:661–70.
    OpenUrl
  25. 25.
    1. Schubert CR,
    2. Cruickshanks KJ,
    3. Fischer ME,
    4. et al
    . Olfactory impairment in an adult population: the Beaver Dam Offspring Study. Chem Senses 2012;37:325–34.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.
    1. Seubert J,
    2. Laukka EJ,
    3. Rizzuto D,
    4. et al
    . Prevalence and correlates of olfactory dysfunction in old age: a population-based study. J Gerontol A Biol Sci Med Sci 2017;72:1072–9.
    OpenUrl
  27. 27.↵
    1. Attems J,
    2. Walker L,
    3. Jellinger KA
    . Olfaction and aging: a mini-review. Gerontology 2015;61:485–90.
    OpenUrlCrossRef
  28. 28.↵
    1. Wilson RS,
    2. Yu L,
    3. Bennett DA
    . Odor identification and mortality in old age. Chem Senses 2011;36:63–7.
    OpenUrlCrossRefPubMedWeb of Science
  29. 29.↵
    1. Adams DR,
    2. Wroblewski KE,
    3. Kern DW,
    4. et al
    . Factors associated with inaccurate self-reporting of olfactory dysfunction in older US adults. Chem Senses 2017;42:223–31.
    OpenUrl
  30. 30.↵
    1. Rawal S,
    2. Hoffman HJ,
    3. Chapo AK,
    4. Duffy VB
    . Sensitivity and specificity of self-reported olfactory function in a home-based study of independent-living, healthy older women. Chemosens Percept 2014;7:108–16.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Olofsson JK,
    2. Freiherr J
    . Neuroimaging of smell and taste. Handb Clin Neurol 2019;164:263–82.
    OpenUrl
  32. 32.↵
    1. Yoshida R,
    2. Miyauchi A,
    3. Yasuo T,
    4. et al
    . Discrimination of taste qualities among mouse fungiform taste bud cells. J Physiol 2009;587:4425–39.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Maheswaran T,
    2. Abikshyeet P,
    3. Sitra G,
    4. Gokulanathan S,
    5. Vaithiyanadane V,
    6. Jeelani S
    . Gustatory dysfunction. J Pharm Bioallied Sci 2014;6:S30–3.
    OpenUrl
  34. 34.↵
    1. Hunt JD,
    2. Reiter ER,
    3. Costanzo RM
    . Etiology of subjective taste loss. Int Forum Allergy Rhinol 2019;9:409–12.
    OpenUrl
  35. 35.↵
    1. Hummel T,
    2. Frasnelli J
    . The intranasal trigeminal system. Handb Clin Neurol 2019;164:119–34.
    OpenUrl
  36. 36.↵
    1. Roper SD
    . TRPs in taste and chemesthesis. Handb Exp Pharmacol 2014;223:827–71.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Hummel T,
    2. Barz S,
    3. Lotsch J,
    4. Roscher S,
    5. Kettenmann B,
    6. Kobal G
    . Loss of olfactory function leads to a decrease of trigeminal sensitivity. Chem Senses 1996;21:75–9.
    OpenUrlCrossRefPubMedWeb of Science
  38. 38.↵
    1. Frasnelli J,
    2. Schuster B,
    3. Hummel T
    . Interactions between olfaction and the trigeminal system: what can be learned from olfactory loss. Cereb Cortex 2007;17:2268–75.
    OpenUrlCrossRefPubMedWeb of Science
  39. 39.↵
    1. de Haro-Licer J,
    2. Roura-Moreno J,
    3. Vizitiu A,
    4. Gonzalez-Fernandez A,
    5. Gonzalez-Ares JA
    . Long term serious olfactory loss in colds and/or flu. Acta Otorrinolaringol Esp 2013;64:331–8.
    OpenUrl
  40. 40.↵
    1. Soler ZM,
    2. Patel ZM,
    3. Turner JH,
    4. Holbrook EH
    . A primer on viral-associated olfactory loss in the era of COVID-19. Int Forum Allergy Rhinol 2020;10:814–20.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Agyeman AA,
    2. Chin KL,
    3. Landersdorfer CB,
    4. Liew D,
    5. Ofori-Asenso R
    . Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc 2020;95:1621–31.
    OpenUrlPubMed
  42. 42.↵
    1. Moein ST,
    2. Hashemian SM,
    3. Mansourafshar B,
    4. Khorram-Tousi A,
    5. Tabarsi P,
    6. Doty RL
    . Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 2020;10:944–50.
    OpenUrlCrossRefPubMed
  43. 43.↵
    1. Suzuki M,
    2. Saito K,
    3. Min WP,
    4. et al
    . Identification of viruses in patients with postviral olfactory dysfunction. Laryngoscope 2007;117:272–7.
    OpenUrlCrossRefPubMedWeb of Science
  44. 44.↵
    1. Imam SA,
    2. Lao WP,
    3. Reddy P,
    4. Nguyen SA,
    5. Schlosser RJ
    . Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD? World J Otorhinolaryngol Head Neck Surg 2020;6:S26–S32.
    OpenUrl
  45. 45.↵
    1. Hura N,
    2. Xie DX,
    3. Choby GW,
    4. et al
    . Treatment of post-viral olfactory dysfunction: an evidence-based review with recommendations. Int Forum Allergy Rhinol 2020;10:1065–86.
    OpenUrl
  46. 46.↵
    1. Iannuzzi L,
    2. Salzo AE,
    3. Angarano G,
    4. et al
    . Gaining back what is lost: Recovering the sense of smell in mild to moderate patients after COVID-19. Chem Senses 2020;45:875–81.
    OpenUrl
  47. 47.↵
    1. Potter MR,
    2. Chen JH,
    3. Lobban NS,
    4. Doty RL
    . Olfactory dysfunction from acute upper respiratory infections: relationship to season of onset. Int Forum Allergy Rhinol 2020;10:706–12. Jun.
    OpenUrlPubMed
  48. 48.↵
    1. Reden J,
    2. Mueller A,
    3. Mueller C,
    4. et al
    . Recovery of olfactory function following closed head injury or infections of the upper respiratory tract. Arch Otolaryngol Head Neck Surg 2006;132:265–9.
    OpenUrlCrossRefPubMedWeb of Science
  49. 49.↵
    1. Lee DY,
    2. Lee WH,
    3. Wee JH,
    4. Kim JW
    . Prognosis of postviral olfactory loss: follow-up study for longer than one year. Am J Rhinol Allergy 2014;28:419–22.
    OpenUrl
  50. 50.↵
    1. Kim DH,
    2. Kim SW,
    3. Hwang SH,
    4. et al
    . Prognosis of olfactory dysfunction according to etiology and timing of treatment. Otolaryngol Head Neck Surg 2017;156:371–7.
    OpenUrlCrossRef
  51. 51.↵
    1. Temmel AF,
    2. Quint C,
    3. Schickinger-Fischer B,
    4. Klimek L,
    5. Stoller E,
    6. Hummel T
    . Characteristics of olfactory disorders in relation to major causes of olfactory loss. Arch Otolaryngol Head Neck Surg 2002;128:635–41.
    OpenUrlCrossRefPubMedWeb of Science
  52. 52.↵
    1. D'Alonzo GE Jr.
    . Scope and impact of allergic rhinitis. J Am Osteopath Assoc 2002;102:S2–kS6.
    OpenUrlPubMed
  53. 53.↵
    1. Stuck BA,
    2. Hummel T
    . Olfaction in allergic rhinitis: A systematic review. J Allergy Clin Immunol 2015;136:1460–70.
    OpenUrl
  54. 54.
    1. DeConde AS,
    2. Soler ZM
    . Chronic rhinosinusitis: Epidemiology and burden of disease. Am J Rhinol Allergy 2016;30:134–9.
    OpenUrl
  55. 55.↵
    1. Ahmed OG,
    2. Rowan NR
    . Olfactory dysfunction and chronic rhinosinusitis. Immunol Allergy Clin North Am 2020;40:223–32.
    OpenUrl
  56. 56.
    1. Alt JA,
    2. Mace JC,
    3. Buniel MC,
    4. Soler ZM,
    5. Smith TL
    . Predictors of olfactory dysfunction in rhinosinusitis using the brief smell identification test. Laryngoscope 2014;124:E259–66.
    OpenUrl
  57. 57.
    1. Fokkens WJ,
    2. Lund VJ,
    3. Mullol J,
    4. et al
    . EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012;50:1–12.
    OpenUrlCrossRefPubMed
  58. 58.
    1. Jiang RS,
    2. Lu FJ,
    3. Liang KL,
    4. et al
    . Olfactory function in patients with chronic rhinosinusitis before and after functional endoscopic sinus surgery. Am J Rhinol 2008;22:445–8.
    OpenUrlCrossRefPubMed
  59. 59.↵
    1. Kohli P,
    2. Naik AN,
    3. Harruff EE,
    4. Nguyen SA,
    5. Schlosser RJ,
    6. Soler ZM
    . The prevalence of olfactory dysfunction in chronic rhinosinusitis. Laryngoscope 2017;127:309–20.
    OpenUrl
  60. 60.↵
    1. Xie DX,
    2. Leland EM,
    3. Seal SM,
    4. Lin SY,
    5. Rowan NR
    . A systematic review and meta-analysis of taste dysfunction in chronic rhinosinusitis. Laryngoscope 2021;131:482–9.
    OpenUrl
  61. 61.↵
    1. Fark T,
    2. Hummel C,
    3. Hahner A,
    4. Nin T,
    5. Hummel T
    . Characteristics of taste disorders. Eur Arch Otorhinolaryngol 2013;270:1855–60.
    OpenUrlCrossRefPubMed
  62. 62.↵
    1. Haxel BR,
    2. Grant L,
    3. Mackay-Sim A
    . Olfactory dysfunction after head injury. J Head Trauma Rehabil 2008;23:407–13.
    OpenUrlCrossRefPubMedWeb of Science
  63. 63.↵
    1. Howell J,
    2. Costanzo RM,
    3. Reiter ER
    . Head trauma and olfactory function. World J Otorhinolaryngol Head Neck Surg 2018;4:39–45.
    OpenUrl
  64. 64.↵
    1. Reiter ER,
    2. DiNardo LJ,
    3. Costanzo RM
    . Effects of head injury on olfaction and taste. Otolaryngol Clin North Am 2004;37:1167–84.
    OpenUrlCrossRefPubMedWeb of Science
  65. 65.↵
    1. Doty RL,
    2. Kamath V
    . The influences of age on olfaction: a review. Front Psychol 2014;5:20.
    OpenUrlCrossRefPubMed
  66. 66.↵
    1. Fullard ME,
    2. Morley JF,
    3. Duda JE
    . Olfactory dysfunction as an early biomarker in Parkinson's disease. Neurosci Bull 2017;33:515–25.
    OpenUrl
  67. 67.
    1. Yoo HS,
    2. Jeon S,
    3. Chung SJ,
    4. et al
    . Olfactory dysfunction in Alzheimer's disease and Lewy body-related cognitive impairment. Alzheimers Dement 2018;14:1243–52.
    OpenUrl
  68. 68.↵
    1. Bathini P,
    2. Brai E,
    3. Auber LA
    . Olfactory dysfunction in the pathophysiological continuum of dementia. Ageing Res Rev 2019;55:100956.
    OpenUrl
  69. 69.↵
    1. Solomon GS,
    2. Petrie WM,
    3. Hart JR,
    4. Brackin HB Jr.
    . Olfactory dysfunction discriminates Alzheimer's dementia from major depression. JNP 1998;10:64–7.
    OpenUrl
  70. 70.
    1. Ponsen MM,
    2. Stoffers D,
    3. Booij J,
    4. van Eck-Smit BL,
    5. Wolters E,
    6. Berendse HW
    . Idiopathic hyposmia as a preclinical sign of Parkinson's disease. Ann Neurol 2004;56:173–81.
    OpenUrlCrossRefPubMedWeb of Science
  71. 71.
    1. Wilson RS,
    2. Schneider JA,
    3. Arnold SE,
    4. Tang Y,
    5. Boyle PA,
    6. Bennett DA
    . Olfactory identification and incidence of mild cognitive impairment in older age. Arch Gen Psychiatry 2007;64:802–8.
    OpenUrlCrossRefPubMedWeb of Science
  72. 72.
    1. Yaffe K,
    2. Freimer D,
    3. Chen H,
    4. et al
    . Olfaction and risk of dementia in a biracial cohort of older adults. Neurology 2017;88:456–62.
    OpenUrlCrossRef
  73. 73.
    1. Schubert CR,
    2. Carmichael LL,
    3. Murphy C,
    4. Klein BE,
    5. Klein R,
    6. Cruickshanks KJ
    . Olfaction and the 5-year incidence of cognitive impairment in an epidemiological study of older adults. J Am Geriatr Soc 2008;56:1517–21.
    OpenUrlCrossRefPubMedWeb of Science
  74. 74.↵
    1. Devanand DP,
    2. Lee S,
    3. Manly J,
    4. et al
    . Olfactory deficits predict cognitive decline and Alzheimer dementia in an urban community. Neurology 2015;84:182–9.
    OpenUrlCrossRefPubMed
  75. 75.↵
    1. Devanand DP,
    2. Lee S,
    3. Luchsinger JA,
    4. et al
    . Intact global cognitive and olfactory ability predicts lack of transition to dementia. Alzheimers Dement 2020;16:326–34.
    OpenUrl
  76. 76.↵
    1. Doty RL
    . Olfactory dysfunction and its measurement in the clinic. World J Otorhinolaryngol Head Neck Surg 2015;1:28–33.
    OpenUrl
  77. 77.↵
    1. Lin SH,
    2. Chu ST,
    3. Yuan BC,
    4. Shu CH
    . Survey of the frequency of olfactory dysfunction in Taiwan. J Chin Med Assoc 2009;72:68–71.
    OpenUrlCrossRefPubMed
  78. 78.
    1. Landis BN,
    2. Hummel T,
    3. Hugentobler M,
    4. Giger R,
    5. Lacroix JS
    . Ratings of overall olfactory function. Chem Senses 2003;28:691–4.
    OpenUrlCrossRefPubMedWeb of Science
  79. 79.↵
    1. Zou LQ,
    2. Linden L,
    3. Cuevas M,
    4. et al
    . Self-reported mini olfactory questionnaire (Self-MOQ): a simple and useful measurement for the screening of olfactory dysfunction. Laryngoscope 2020;130:E786–E790.
    OpenUrl
  80. 80.↵
    1. Gözen ED,
    2. Aliyeva C,
    3. Tevetoğlu F,
    4. et al
    . Evaluation of olfactory function with objective tests in COVID-19-positive patients: a cross-sectional study. Ear Nose Throat J 2021;100:169S–73S. Apr.
    OpenUrl
  81. 81.↵
    1. Hummel T,
    2. Whitcroft KL,
    3. Andrews P,
    4. et al
    . Position paper on olfactory dysfunction. Rhinology 2016;56:1–30.
    OpenUrlCrossRef
  82. 82.↵
    1. Doty RL
    . Psychophysical testing of smell and taste function. Handb Clin Neurol 2019;164:229–46.
    OpenUrl
  83. 83.↵
    1. Doty RL,
    2. Marcus A,
    3. Lee WW
    . Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT). Laryngoscope 1996;106:353–6.
    OpenUrlCrossRefPubMedWeb of Science
  84. 84.
    1. Sorokowska A,
    2. Oleszkiewicz A,
    3. Minovi A,
    4. Konnerth CG,
    5. Hummel T
    . Fast screening of olfactory function using the Q-Sticks Test. ORL J Otorhinolaryngol Relat Spec 2019;81:245–51.
    OpenUrl
  85. 85.
    1. Jackman AH,
    2. Doty RL
    . Utility of a three-item smell identification test in detecting olfactory dysfunction. Laryngoscope 2005;115:2209–12.
    OpenUrlCrossRefPubMedWeb of Science
  86. 86.↵
    1. Doty RL,
    2. Shaman P,
    3. Kimmelman CP,
    4. Dann MS
    . University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984;94:176–8.
    OpenUrlCrossRefPubMedWeb of Science
  87. 87.
    1. Doty RL,
    2. Wylie C,
    3. Potter M,
    4. Beston R,
    5. Cope B,
    6. Majam K
    . Clinical validation of the olfactory detection threshold module of the Snap & Sniff(R) olfactory test system. Int Forum Allergy Rhinol 2019;9:986–92.
    OpenUrl
  88. 88.
    1. Calvo-Henriquez C,
    2. Maldonado-Alvarado B,
    3. Chiesa-Estomba C,
    4. et al
    . Ethyl alcohol threshold test: a fast, reliable and affordable olfactory Assessment tool for COVID-19 patients. Eur Arch Otorhinolaryngol 2020;277:2783–92.
    OpenUrl
  89. 89.
    1. Pierce JD Jr..,
    2. Doty RL,
    3. Amoore JE
    . Analysis of position of trial sequence and type of diluent on the detection threshold for phenyl ethyl alcohol using a single staircase method. Percept Mot Skills 1996;82:451–8.
    OpenUrlCrossRefPubMedWeb of Science
  90. 90.
    1. Kobal G,
    2. Hummel T,
    3. Sekinger B,
    4. Barz S,
    5. Roscher S,
    6. Wolf S
    . “Sniffin' sticks”: screening of olfactory performance. Rhinology 1996;34:222–6.
    OpenUrlPubMed
  91. 91.
    1. Doty R
    . The Odor Threshold Test administration manual. Haddon Hts., NJ: Sensonics. Inc; 2000. [Database]
  92. 92.↵
    1. Rumeau C,
    2. Nguyen DT,
    3. Jankowski R
    . How to assess olfactory performance with the Sniffin' Sticks test. Eur Ann Otorhinolaryngol Head Neck Dis 2016;133:203–6.
    OpenUrlCrossRefPubMed
  93. 93.↵
    1. Ozay H,
    2. Cakir A,
    3. Ecevit MC
    . Retronasal olfaction test methods: a systematic review. Balkan Med J 2019;36:49–59.
    OpenUrl
  94. 94.↵
    1. Furukawa M,
    2. Kamide M,
    3. Ohkado T,
    4. Umeda R
    . Electro-olfactogram (EOG) in olfactometry. Auris Nasus Larynx 1989;16:33–8.
    OpenUrlPubMed
  95. 95.↵
    1. Roberts RJ,
    2. Sheehan W,
    3. Thurber S,
    4. Roberts MA
    . Functional neuro-imaging and post-traumatic olfactory impairment. Indian J Psychol Med 2010;32:93–8.
    OpenUrlCrossRefPubMed
  96. 96.
    1. Rombaux P,
    2. Huart C,
    3. Mouraux A
    . Assessment of chemosensory function using electroencephalographic techniques. Rhinology 2012;50:13–21.
    OpenUrlPubMed
  97. 97.↵
    1. Soler ZM,
    2. Pallanch JF,
    3. Sansoni ER,
    4. et al
    . Volumetric computed tomography analysis of the olfactory cleft in patients with chronic rhinosinusitis. International Forum of Allergy and Rhinology 2015;5:846–54.
    OpenUrl
  98. 98.↵
    1. Walter WG,
    2. Cooper R,
    3. Aldridge VJ,
    4. McCallum WC,
    5. Winter AL
    . Contingent negative variation: an electric sign of sensorimotor association and expectancy in the human brain. Nature 1964;203:380–4.
    OpenUrlCrossRefPubMedWeb of Science
  99. 99.↵
    1. Rawal S,
    2. Hoffman HJ,
    3. Honda M,
    4. Huedo-Medin TB,
    5. Duffy VB
    . The taste and smell protocol in the 2011–2014 US National Health and Nutrition Examination Survey (NHANES): Test–retest reliability and validity testing. Chemosens Percept 2015;8:138–48.
    OpenUrl
  100. 100.
    1. Bernhardson BM,
    2. Olson K,
    3. Baracos VE,
    4. Wismer WV
    . Reframing eating during chemotherapy in cancer patients with chemosensory alterations. Eur J Oncol Nurs 2012;16:483–90.
    OpenUrlPubMed
  101. 101.↵
    1. Mathey MF
    . Assessing appetite in Dutch elderly with the Appetite, Hunger and Sensory Perception (AHSP) questionnaire. J Nutr Health Aging 2001;5:22–8.
    OpenUrlPubMed
  102. 102.↵
    1. Doty RL
    . Measurement of chemosensory function. World J Otorhinolaryngol Head Neck Surg 2018;4:11–28.
    OpenUrl
  103. 103.
    1. Stinton N,
    2. Atif MA,
    3. Barkat N,
    4. Doty RL
    . Influence of smell loss on taste function. Behav Neurosci 2010;124:256–64.
    OpenUrlCrossRefPubMed
  104. 104.↵
    1. Bartoshuk LM,
    2. Gent J,
    3. Catalanotto FA,
    4. Goodspeed RB
    . Clinical evaluation of taste. Am J Otolaryngol 1983;4:257–60.
    OpenUrlPubMedWeb of Science
  105. 105.↵
    1. Getchell TV,
    2. Doty RL,
    3. Bartoshuk LM,
    4. Snow JB Jr.
    1. Frank ME,
    2. Smith DV
    . Electrogustometry: A simple way to test taste. In: Getchell TV, Doty RL, Bartoshuk LM, Snow JB Jr. eds. Smell and Taste in Health and Disease. New York, NY: Raven Press; 1991:503–514.
  106. 106.↵
    1. Parma V,
    2. Ohla K,
    3. Veldhuizen MG
    , GCCR Group Authoret al. More than smell—COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chem Senses 2020;45:609–22.
    OpenUrl
  107. 107.↵
    1. Hummel T,
    2. Futschik T,
    3. Frasnelli J,
    4. Huttenbrink KB
    . Effects of olfactory function, age, and gender on trigeminally mediated sensations: a study based on the lateralization of chemosensory stimuli. Toxicol Lett 2003;140–141:273–80.
    OpenUrl
  108. 108.↵
    1. Kobal G,
    2. Van Toller S,
    3. Hummel T
    . Is there directional smelling? Experientia 1989;45:130–2.
    OpenUrlCrossRefPubMedWeb of Science
  109. 109.↵
    1. Huart C,
    2. Hummel T,
    3. Kaehling C,
    4. et al
    . Development of a new psychophysical method to assess intranasal trigeminal chemosensory function. Rhinology 2019;57:375–84.
    OpenUrl
  110. 110.↵
    1. Hummel T,
    2. Kaehling C,
    3. Grosse F
    . Automated assessment of intranasal trigeminal function. Rhinology. Mar 2016;54:27–31.
    OpenUrl
  111. 111.↵
    1. Van Regemorter V,
    2. Hummel T,
    3. Rosenzweig F,
    4. Mouraux A,
    5. Rombaux P,
    6. Huart C
    . Mechanisms linking olfactory impairment and risk of mortality. Front Neurosci 2020;14:140.
    OpenUrlCrossRef
  112. 112.↵
    1. Hummel T,
    2. Rissom K,
    3. Reden J,
    4. Hähner A,
    5. Weidenbecher M,
    6. Hüttenbrink K-B
    . Effects of olfactory training in patients with olfactory loss. Laryngoscope 2009;119:496–9.
    OpenUrlCrossRefPubMedWeb of Science
  113. 113.↵
    1. Birte-Antina W,
    2. Ilona C,
    3. Antje H,
    4. Thomas H
    . Olfactory training with older people. Int J Geriatr Psychiatry 2018;33:212–20.
    OpenUrl
  114. 114.↵
    1. Fechner A,
    2. Fong S,
    3. McGovern P
    . A review of Kallmann syndrome: genetics, pathophysiology, and clinical management. Obstet Gynecol Surv 2008;63:189–94.
    OpenUrlCrossRefPubMed
  115. 115.↵
    1. Yousem DM,
    2. Geckle RJ,
    3. Bilker W,
    4. McKeown DA,
    5. Doty RL
    . MR evaluation of patients with congenital hyposmia or anosmia. AJR Am J Roentgenol 1996;166:439–43.
    OpenUrlCrossRefPubMedWeb of Science
  116. 116.↵
    1. Luchsinger JA,
    2. Devanand DP
    . Testing olfaction in primary care to detect Alzheimer's disease and other dementias (TOPAD). Reporter. https://reporter.nih.gov/search/0QxT-MyFhEWXIdUXtkGzCA/project-details/10192624.
  117. 117.↵
    1. Krismer F,
    2. Pinter B,
    3. Mueller C,
    4. et al
    . Sniffing the diagnosis: Olfactory testing in neurodegenerative parkinsonism. Parkinsonism Relat Disord 2017;35:36–41.
    OpenUrl
  118. 118.↵
    1. Mori E,
    2. Merkonidis C,
    3. Cuevas M,
    4. Gudziol V,
    5. Matsuwaki Y,
    6. Hummel T
    . The administration of nasal drops in the “Kaiteki” position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects. Eur Arch Otorhinolaryngol 2016;273:939–43.
    OpenUrl
  119. 119.↵
    1. Sur DK,
    2. Scandale S
    . Treatment of allergic rhinitis. Am Fam Physician 2010;81:1440–6.
    OpenUrlPubMedWeb of Science
  120. 120.↵
    1. Sakashita S,
    2. Takayama K,
    3. Nishioka K,
    4. Katoh T
    . Taste disorders in healthy “carriers” and “non-carriers” of Candida albicans and in patients with candidosis of the tongue. J Dermatol 2004;31:890–7.
    OpenUrlPubMed
  121. 121.↵
    1. Huang T,
    2. Wei Y,
    3. Wu D
    . Effects of olfactory training on posttraumatic olfactory dysfunction: a systematic review and meta-analysis. Int Forum Allergy Rhinol 2021;11:1102–12.
    OpenUrl
  122. 122.↵
    1. Kollndorfer K,
    2. Fischmeister FP,
    3. Kowalczyk K,
    4. et al
    . Olfactory training induces changes in regional functional connectivity in patients with long-term smell loss. Neuroimage Clin 2015;9:401–10.
    OpenUrl
  123. 123.
    1. Pekala K,
    2. Chandra RK,
    3. Turner JH
    . Efficacy of olfactory training in patients with olfactory loss: a systematic review and meta-analysis. Int Forum Allergy Rhinol 2016;6:299–307.
    OpenUrlCrossRefPubMed
  124. 124.
    1. Kattar N,
    2. Do TM,
    3. Unis GD,
    4. Migneron MR,
    5. Thomas AJ,
    6. McCoul ED
    . Olfactory training for postviral olfactory dysfunction: systematic review and meta-analysis. Otolaryngol Head Neck Surg 2021;164:244–54.
    OpenUrlCrossRef
  125. 125.↵
    1. Whitcroft KL,
    2. Hummel T
    . Clinical diagnosis and current management strategies for olfactory dysfunction: a review. JAMA Otolaryngol Head Neck Surg 2019;145:846–53.
    OpenUrl
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