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Review ArticleClinical Review

Advances in Diagnosis and Treatment of Latent Tuberculosis Infection

Helena J. Chapman and Michael Lauzardo
The Journal of the American Board of Family Medicine September 2014, 27 (5) 704-712; DOI: https://doi.org/10.3122/jabfm.2014.05.140062
Helena J. Chapman
From the Southeastern National Tuberculosis Center, Division of Infectious Diseases and Global Medicine, University of Florida College of Medicine, Gainesville (HJC, ML); and the Department of Environmental and Global Health, University of Florida, Gainesville (HJC).
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Michael Lauzardo
From the Southeastern National Tuberculosis Center, Division of Infectious Diseases and Global Medicine, University of Florida College of Medicine, Gainesville (HJC, ML); and the Department of Environmental and Global Health, University of Florida, Gainesville (HJC).
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Abstract

In the United States, latent tuberculosis infection (LTBI) affects between 10 and 15 million people, of whom 10% may develop active tuberculosis disease. People at increased risk for tuberculosis reactivation include recent immigrants from countries with a high incidence of tuberculosis, children younger than age 5, people who have been infected with Mycobacterium tuberculosis within the past 2 years, or people with immunosuppression for a variety of reasons. Appropriate diagnosis and treatment of LTBI are critical for controlling and eventually eliminating tuberculosis as a public health problem. Although the tuberculin skin test is the traditional diagnostic measure for LTBI, reduced specificity has promoted the development and utilization of the interferon-γ release assays as an in vitro blood test with specific antigens to M. tuberculosis (QuantiFERON-TB Gold In-Tube test and the T.SPOT-TB test are commercially available). Despite the rise of the new diagnostic tests, however, there is still no gold standard for diagnosing LTBI, and epidemiologic risks and comorbidities need to be taken into account before initiating therapy. Current diagnostic tests combined with recommended treatment regimens are valuable tools that, when used correctly, promise to hurry the elimination of tuberculosis.

  • Infectious Diseases
  • Respiratory Tract Diseases
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The Journal of the American Board of Family     Medicine: 27 (5)
The Journal of the American Board of Family Medicine
Vol. 27, Issue 5
September-October 2014
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Advances in Diagnosis and Treatment of Latent Tuberculosis Infection
Helena J. Chapman, Michael Lauzardo
The Journal of the American Board of Family Medicine Sep 2014, 27 (5) 704-712; DOI: 10.3122/jabfm.2014.05.140062

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Advances in Diagnosis and Treatment of Latent Tuberculosis Infection
Helena J. Chapman, Michael Lauzardo
The Journal of the American Board of Family Medicine Sep 2014, 27 (5) 704-712; DOI: 10.3122/jabfm.2014.05.140062
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  • Respiratory Tract Diseases

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