How Long Does It Take to Assess Literacy Skills in Clinical Practice? ===================================================================== * Kristen Johnson * Barry D. Weiss ## Abstract *Background:* Health literacy screening is often not performed in clinical settings. One possible reason is the concern about the time involved in performing such assessments. Our objective was to measure the time required to administer the Newest Vital Sign (NVS) literacy assessment instrument to English-speaking primary care patients. *Methods:* The NVS was administered to 78 consecutive English-speaking patients in an outpatient primary care clinic. The length of time to complete the NVS was timed with a stopwatch. *Results:* The average time to complete the NVS was 2.9 minutes (95% confidence limit, 2.6–3.1 min). *Conclusion:* The NVS is a health literacy screening tool of sufficient brevity to be considered for use in primary care practices. Health literacy is the degree to which a person has the ability to obtain, process, and understand health information needed to make appropriate health decisions.1–3 It involves the ability to use and interpret text, documents, and numbers. People with limited literacy have less knowledge about their health problems,4–10 higher hospitalization rates,11,12 higher health care costs,13–16 and worse health status17–22 than people with adequate literacy. These associations are seen in a variety of studies involving different populations, and they are present even after adjusting for potentially confounding sociodemographic variables. If clinicians have knowledge of the literacy skills of their patients, they can tailor health information so that it is provided in a format that their patients can understand.23 Despite the aforementioned implications of limited health literacy, there is currently no universally accepted method for assessing literacy in clinical settings. Some clinicians use level of education as a surrogate marker of literacy, but education level overestimates actual literacy skills.24 Other clinicians who screen for literacy do so by asking patients how well they read, but this approach is also inaccurate because the majority of patients who have limited literacy report they read “well.” Other clinicians do not screen for literacy for fear of offending patients, citing concerns that people with limited literacy are ashamed of this limitation25–27 and might, therefore, be unwilling to undergo a literacy assessment. Evidence suggests otherwise, however: a recent study involving nearly 600 patients indicates that fully 99% of patients seen in both public and private practice settings readily participated in literacy screening, and there was no decrease in patient satisfaction in practices that undertake such screening.28 Another small study indicated that patients do not object to literacy screening if questions are asked in a sensitive way.29 Finally, the time needed for literacy assessment may also be an obstacle to screening, especially given that the average primary care office visit lasts only 17 minutes.30 The Test of Functional Health Literacy in Adults, a widely used health literacy assessment tool, has good psychometric characteristics and is available in both English and Spanish, but the time required for administration limits it functionality in practice: 18 to 22 minutes for the full version and 7 to 10 minutes for the short version.31,32 The other commonly used tool, the Rapid Estimate of Adult Literacy in Medicine, can be administered in less than 3 minutes, but it is only available in English.33 A new brief instrument for literacy screening in health care settings, The Newest Vital Sign (NVS), is available in both English and Spanish and has recently been validated.34 The validation study for the NVS showed that, when compared with the Test of Functional Health Literacy in Adults, the NVS's area under the receiver–operator characteristics curve for predicting limited health literacy was 0.88 for the English version and 0.71 for the Spanish version; these values are higher than those of many commonly used clinical screening methods such as the CAGE questionnaire to detect alcohol abuse35,36 and breast self-examinations to screen for cancer.37 According to information provided in the validation study, the English version of the NVS can be administered in an average of 3 minutes, but this time estimate was based on a series of only 24 timed administrations. Our objective was to confirm the length of time required to administer the NVS in English by administering it to a larger sample of patients. ## Methods The University of Arizona Human Subjects Protection Program approved the study methods. All participants gave informed consent. ### Participants Participants were consecutive patients being seen by residents and attending physicians in a university-based primary care clinic. The patients’ physicians were not involved in selection or recruitment of study participants. A single researcher (KJ) approached patients, explained the nature of the study, and requested their participation. The researcher approached all patients during the days when she was available in the clinic during the time period of the study. All participants were 18 years of age or older and read English as their first or primary language. Subjects were excluded if they were younger than 18, if they were unable to meaningfully converse with the researcher in English, or if they were being seen in clinic for an acute emergency that precluded participation in a research project. ### Instrument Administering the NVS involves presenting patients with a nutrition label (Fig. 1) and then asking patients 6 questions about the content of the label. The questions ask patients to compute the number of calories in various amounts of food; to interpret the effect on daily fat and carbohydrate consumption if the amount of the food is changed; to identify ingredients in the food; and to determine whether the food can be consumed if an individual is allergic to one of those ingredients. ![Figure 1.](http://www.jabfm.org/https://www.jabfm.org/content/jabfp/21/3/211/F1.medium.gif) [Figure 1.](http://www.jabfm.org/content/21/3/211/F1) Figure 1. **The nutrition label used in the Newest Vital Sign assessment.** Scores range from 0 to 6, depending on the number of correct responses. Scores of 0 to 1 indicate that low health literacy is likely, scores of 2 to 3 indicate the possibility of low health literacy, and scores of 4 to 6 indicate adequate health literacy.34 In this study, the NVS was administered by a single researcher (KJ), using methods provided with the instrument.38 ### Measures During administration of the NVS, the researcher used a stopwatch measure the amount of time it took for participants to complete the NVS assessment. Demographic information about each participant was also collected. ## Results A total of 78 consecutive patients were recruited. All patients asked to participate agreed to do so. Their average age was 44 years (S.D. = 16, range 21 to 81). Other demographic characteristics of the participants are shown in Table 1. View this table: [Table 1.](http://www.jabfm.org/content/21/3/211/T1) Table 1. **Demographic Characteristics of Patients** Timing of the NVS was reported as mean (SD) and 95% confidence limits.39 The average time to complete the NVS was 2.9 minutes (SD, 1.03 min; 95% CL, 2.67–3.13). The average NVS score was 3.7 (SD, 1.9) out of a maximum score of 6. ## Discussion Timing of the NVS in this larger sample of English-speaking patients is consistent with timing reported in the initial NVS validation study. The NVS takes approximately 3 minutes to complete. The short time required to perform the assessment, combined with the results of a recent study showing that 99% of patients agree to literacy assessment in practice,28 indicate that the NVS is suitable for literacy screening in clinical settings. The findings of this study are limited, however, by the fact that we included only English-speaking patients and thus cannot comment on the length of time it takes to administer the NVS in Spanish. In the validation study, the average time for a series of 36 Spanish-speaking patients was slightly longer than for English-speaking patients (3.4 vs 2.9 min). It is reasonable to assume that a larger series of Spanish-speaking patients would show a similar time requirement. A second limitation may be the educational background of our population; 81% had completed a high school or greater level of education. It is possible that the NVS would take longer to administer in a population of patients with a lower education level. However, education level has repeatedly been shown not to correlate well with literacy. Indeed, approximately one quarter of people who score at the lowest level of literacy in national surveys have completed high school.24 This makes the education level of our participants of less concern when applying our results to less-educated populations. ## Conclusion The English version of the NVS can be administered to patients in approximately 3 minutes. Future research should address timing of the Spanish version of the NVS, how best to administer the NVS in primary care practice, and how, or if, physicians change their methods of communication with patients based on NVS results. ## Notes * This article was externally peer reviewed. * *Funding:* none. * *Conflict of interest:* Dr. Weiss has received research grants from Pfizer, Inc. to develop and test the Newest Vital Sign literacy assessment instrument. * Received for publication September 21, 2007. * Revision received January 18, 2008. * Accepted for publication January 28, 2008. ## References 1. Committee on Health Literacy, Institute of Medicine, Nielsen-Bohlman LN, Panzer AM, Kindig DA, eds. Health literacy: a prescription to end confusion. Washington, DC: The National Academies Press; 2004. 2. Berkman ND, DeWalt DA, Pignone MP, et al. Literacy and health outcomes. Summary, evidence report/technology assessment no. 87. AHRQ Publication No. 04-E007–1. Rockville (MD): Agency for Healthcare Research and Quality; 2004. 3. Schwartzberg JG, VanGeest, JB, Wang CC, eds. Understanding health literacy: implications for medicine and public health. Chicago (IL): American Medical Association Press; 2004. 4. Williams MV, Baker DW, Parker RM, Nurss JR. Relationship of functional health literacy to patients’ knowledge of their chronic disease: a study of patients with hypertension or diabetes. Arch Int Med 1998; 158: 166–72. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1001/archinte.158.2.166&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=9448555&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000071556300006&link_type=ISI) 5. Arnold CL, Davis TC, Berkel HJ, Jackson RH, Nandy I, London S. Smoking status, reading level, and knowledge of tobacco effects among low-income pregnant women. Prev Med 2001; 32: 313–20. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1006/pmed.2000.0815&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=11304092&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000167944200002&link_type=ISI) 6. Williams MV, Baker DW, Honig EG, Lee TM, Nowlan A. Inadequate literacy is a barrier to asthma knowledge and self-care. Chest 1998; 114: 1008–15. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1378/chest.114.4.1008&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=9792569&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000076498000014&link_type=ISI) 7. Davis TC, Arnold C, Berkel HJ, Nandy I, Jackson RH, Glass J. Knowledge and attitude on screening mammography among low-literate, low-income women. Cancer 1996; 78: 1912–20. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1002/(SICI)1097-0142(19961101)78:9<1912::AID-CNCR11>3.0.CO;2-0&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=8909311&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=A1996VN85200011&link_type=ISI) 8. Davis TC, Dolan NC, Ferreira MR, et al. The role of inadequate health literacy skills in colorectal cancer screening. Cancer Invest 2001; 19: 193–200. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1081/CNV-100000154&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=11296623&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000167698300010&link_type=ISI) 9. Gazmararian JA, Williams MV, Peel J, Baker DW. Health literacy and knowledge of chronic disease. Patient Educ Couns 2003; 51: 267–75. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1016/S0738-3991(02)00239-2&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=14630383&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000187235200009&link_type=ISI) 10. Nolan NC, Ferreira MR, Davis TC, et al. Colorectal cancer screening knowledge, attitudes, and beliefs among veterans: does literacy make a difference? J Clin Oncol 2004; 22: 2617–22. [Abstract/FREE Full Text](http://www.jabfm.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamNvIjtzOjU6InJlc2lkIjtzOjEwOiIyMi8xMy8yNjE3IjtzOjQ6ImF0b20iO3M6MjA6Ii9qYWJmcC8yMS8zLzIxMS5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=) 11. Baker DW, Gazmararian JA, Williams MV, et al. Functional health literacy and the risk of hospital admission among Medicare managed care enrollees. Am J Public Health 2002; 92: 1278–83. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.2105/AJPH.92.8.1278&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=12144984&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000177109800022&link_type=ISI) 12. Baker DW, Parker RM, Williams MV, Clark WS. Health literacy and the risk of hospital admission. J Gen Intern Med 1998; 13: 791–8. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1046/j.1525-1497.1998.00242.x&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=9844076&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000077496000001&link_type=ISI) 13. Weiss BD, Palmer R. Relationship between health care costs and very low literacy skills in a medically needy and indigent Medicaid population. J Am Board Fam Med 2004; 17: 44–7. [Abstract/FREE Full Text](http://www.jabfm.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NToiamFiZnAiO3M6NToicmVzaWQiO3M6NzoiMTcvMS80NCI7czo0OiJhdG9tIjtzOjIwOiIvamFiZnAvMjEvMy8yMTEuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 14. Howard DH, Gazmararian JA, Parker RM. The impact of low health literacy on medical costs for Medicare managed care enrollees. Am J Med 2005; 118: 371–7. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1016/j.amjmed.2005.01.010&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=15808134&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000228275200008&link_type=ISI) 15. Friedland RB. Understanding health literacy: new estimates of the costs of inadequate health literacy. Washington, DC: National Academy on an Aging Society; 1998. 16. Vernon J. Low health literacy: an economic drain on the US healthcare system. Presented at National Press Club, Washington, DC, 10 October 2007. 17. Baker DW, Parker RM, Williams MV, Clark WS, Nurss J. The relationship of patient reading ability to self-reported health and use of health services. Am J Public Health 1997; 87: 1027–30. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.2105/AJPH.87.6.1027&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=9224190&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=A1997XJ85900031&link_type=ISI) 18. Kalichman SC, Rompa D. Functional health literacy is associated with health status and health-related knowledge in people living with HIV-AIDS. J Acquir Immune Defic Syndr 2000; 25: 337–44. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1097/00042560-200012010-00007&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=11114834&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000165867200007&link_type=ISI) 19. Schillinger D, Grumbach K, Piette J, et al. Association of health literacy with diabetes outcomes. JAMA 2002; 288: 475–82. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1001/jama.288.4.475&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=12132978&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000176955400030&link_type=ISI) 20. Weiss BD, Hart G, McGee D, D’Estelle S. Health status of illiterate adults: relation between literacy and health status among persons with low literacy skills. J Am Board Fam Pract 1992; 5: 257–64. [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=1580173&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) 21. Bennett CL, Ferreira MR, Davis TC, et al. Relation between literacy, race, and stage of presentation among low-income patients with prostate cancer. J Clin Oncol 1998; 16: 3101–4. [Abstract/FREE Full Text](http://www.jabfm.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6MzoiamNvIjtzOjU6InJlc2lkIjtzOjk6IjE2LzkvMzEwMSI7czo0OiJhdG9tIjtzOjIwOiIvamFiZnAvMjEvMy8yMTEuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 22. Sudore RL, Yaffe K, Satterfield S, et al. Limited literacy and mortality in the elderly: the health, aging, and body composition study. J Gen Intern Med 2006; 21: 806–12. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1111/j.1525-1497.2006.00539.x&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=16881938&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000238888800003&link_type=ISI) 23. Weiss BD. Health literacy: a manual for clinicians. Chicago (IL): American Medical Association Foundation; 2003. 24. National Center for Education Statistics. National assessment of adult literacy: a first look at the literacy of America's adults in the 21st century. NCES Publication No. 2006470. Washington, DC: National Center for Education Statistics; 2005. 25. Parikh NS, Parker RM, Nurss JR, Baker DW, Williams MV. Shame and health literacy: the unspoken connection. Patient Educ Couns 1996; 27: 33–9. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1016/0738-3991(95)00787-3&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=8788747&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=A1996TN62600006&link_type=ISI) 26. Baker DW, Parker RM, Williams MV, et al. The health care experience of patients with low literacy. Arch Fam Med 1996; 5: 329–34. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1001/archfami.1996.01850430019010&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=8640322&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=A1996UQ47400009&link_type=ISI) 27. Wolf MS, Williams MV, Parker RM, Parikh NS, Nowlan AW, Baker DW. Patients’ shame and attitudes toward discussing the results of literacy screening. J Health Commun 2007; 12: 721–32. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1080/10810730701672173&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=18030638&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000251740400003&link_type=ISI) 28. Ryan JG, Leguen F, Weiss BD, et al. Will patients agree to have their literacy skills assessed in clinical practice? Health Educ Re; in press. 29. Farrell TW, Chandran R, Gramling R. Understanding the role of shame in the clinical assessment of health literacy. Fam Med; in press. 30. Woodwell DA, Cherry DK. National Ambulatory Medical Care Survey: 2002 summary. Advance data from vital and health statistics; no. 346. Hyattsville (MD): National Center for Health Statistics; 2004. 31. Baker DW, Williams MV, Parker RM, Gazmararian JA, Nurss J. Development of a brief test to measure functional health literacy. Patient Educ Couns 1999; 38: 33–42. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1016/S0738-3991(98)00116-5&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=14528569&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000082751500005&link_type=ISI) 32. Parker R, Baker D, Williams M, Nurss J. The test of functional health literacy in adults (TOFHLA): a new instrument for measuring patients’ literacy skills. J Gen Intern Med 1995; 10: 537–45. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1007/BF02640361&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=8576769&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=A1995TC87400001&link_type=ISI) 33. Davis TC, Long S, Jackson R, et al. Rapid estimate of adult literacy in medicine: a shortened screening instrument. Fam Med 1993; 25: 391–5. [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=8349060&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) 34. Weiss BD, Mays MZ, Martz W, et al. Quick assessment of literacy in primary care: the Newest Vital Sign. Ann Fam Med 2005; 3: 514–22. [Abstract/FREE Full Text](http://www.jabfm.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6ODoiYW5uYWxzZm0iO3M6NToicmVzaWQiO3M6NzoiMy82LzUxNCI7czo0OiJhdG9tIjtzOjIwOiIvamFiZnAvMjEvMy8yMTEuYXRvbSI7fXM6ODoiZnJhZ21lbnQiO3M6MDoiIjt9) 35. Bradley KA, Boyd-Wickizer J, Powell SH, Burman ML. Alcohol screening questionnaires in women. A critical review. JAMA 1998; 280: 166–71. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1001/jama.280.2.166&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=9669791&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000074608400033&link_type=ISI) 36. Cook RL, Chung T, Kelly TM, Clark DB. Alcohol screening in young persons attending a sexually transmitted disease clinic. Comparison of AUDIT, CRAFFT, and CAGE instruments. J Gen Intern Med 2005; 20: 1–6. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1111/j.1525-1497.2005.40052.x&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=15693920&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000226899900001&link_type=ISI) 37. Elmore JG, Armstrong K, Lehman CD, Fletcher SW. Screening for breast cancer. JAMA 2005; 293: 1245–56. [CrossRef](http://www.jabfm.org/lookup/external-ref?access_num=10.1001/jama.293.10.1245&link_type=DOI) [PubMed](http://www.jabfm.org/lookup/external-ref?access_num=15755947&link_type=MED&atom=%2Fjabfp%2F21%2F3%2F211.atom) [Web of Science](http://www.jabfm.org/lookup/external-ref?access_num=000227498400025&link_type=ISI) 38. Pfizer. The Newest Vital Sign: a new health literacy assessment tool for health care providers. Available at [http://www.clearhealthcommunication.org/physicians-providers/newest-vital-sign.html](http://www.clearhealthcommunication.org/physicians-providers/newest-vital-sign.html). Accessed 28 February 2008. 39. Dimension Research, Inc. Confidence interval for means calculator. Available at [http://www.dimensionresearch.com/resources/calculators/conf\_means.html](http://www.dimensionresearch.com/resources/calculators/conf_means.html). Accessed 28 February 2008.