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OtherEvidence-Based Clinical Medicine

Clinical Utility of Interferon Gamma Assay in the Diagnosis of Tuberculosis

Miguel G. Madariaga, Ziba Jalali and Susan Swindells
The Journal of the American Board of Family Medicine November 2007, 20 (6) 540-547; DOI: https://doi.org/10.3122/jabfm.2007.06.070109
Miguel G. Madariaga
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Ziba Jalali
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Susan Swindells
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Abstract

Newly developed assays that measure the production of cellular interferon gamma are useful diagnostic tools for the diagnosis of tuberculosis and may potentially replace or complement the tuberculin skin test in some circumstances. Importantly, interferon gamma release assays are more specific than tuberculin skin tests. Unfortunately the tests do not differentiate between active or latent infection. In addition, immunocompromised patients are more likely to have indeterminate results. The current interferon gamma release assays test approved in the United States is costly and requires drawing blood and processing within 12 hours of collection. This study discusses the potential benefits and drawbacks in patients, including those who are immunocompromised.

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The Journal of the American Board of Family Medicine: 20 (6)
The Journal of the American Board of Family Medicine
Vol. 20, Issue 6
November-December 2007
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Clinical Utility of Interferon Gamma Assay in the Diagnosis of Tuberculosis
Miguel G. Madariaga, Ziba Jalali, Susan Swindells
The Journal of the American Board of Family Medicine Nov 2007, 20 (6) 540-547; DOI: 10.3122/jabfm.2007.06.070109

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Clinical Utility of Interferon Gamma Assay in the Diagnosis of Tuberculosis
Miguel G. Madariaga, Ziba Jalali, Susan Swindells
The Journal of the American Board of Family Medicine Nov 2007, 20 (6) 540-547; DOI: 10.3122/jabfm.2007.06.070109
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