Introduction: The management of children with fever without apparent sources (FWAS) is
difficult. This study aimed to evaluate the diagnostic accuracy of procalcitonin (PCT) in …

Sepsis remains the leading cause of childhood mortality worldwide. The evolving definition
of pediatric sepsis is extrapolated from adult studies. Although lacking formal validation in …

Background Overprescription of antibiotics for lower respiratory tract infections (LRTIs) in
children is common, partly due to diagnostic uncertainty, in which case the addition of point …

Background The use of point of care (POC) tests varies across Europe, but research into
what drives this variability is lacking. Focusing on CRP POC tests, we aimed to understand …

Objective To better understand testing patterns in children, we measured temporal trends in
paediatric testing from 2005 to 2019 in Oxfordshire, UK. Design Descriptive study of …

Febrile neutropenia is a common complication during chemotherapy in paediatric cancer
care. In this setting, clinical features and current diagnostic tests do not reliably distinguish …

A systematic review of literature from 2011 to 2016 was performed, in order to evaluate the
diagnostic performance of inflammatory biomarkers in children with fever without apparent …

Inflammatory markers are non-specific blood tests including C-reactive protein (CRP),
erythrocyte sedimentation rate (ESR) and plasma viscosity (PV). These tests are commonly …

Sepsis is a complex inflammatory response that is strongly associated with multiple organ
dysfunctions and considered as a major cause of morbidity and mortality worldwide. The …

Background Septicemia is a serious condition in pediatric population which highly depends
on immediate diagnosis and treatment in terms of mortality and morbidity rate. Developing …