Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response
…, S Matti, MJ Leckie, V Kanabar, J Khan, SJ Warrington… - The Lancet, 2000 - thelancet.com
Background Interleukin-12 (IL-12) is a macrophage-derived cytokine that modulates T
lymphocyte responses and has the capacity to suppress allergic and eosinophilic inflammation. …
lymphocyte responses and has the capacity to suppress allergic and eosinophilic inflammation. …
[HTML][HTML] Safety and efficacy of RNAi therapy for transthyretin amyloidosis
…, T Mant, J Perez, J Chiesa, S Warrington… - … England Journal of …, 2013 - Mass Medical Soc
Background Transthyretin amyloidosis is caused by the deposition of hepatocyte-derived
transthyretin amyloid in peripheral nerves and the heart. A therapeutic approach mediated by …
transthyretin amyloid in peripheral nerves and the heart. A therapeutic approach mediated by …
[HTML][HTML] Physiology, catecholamines
S Paravati, A Rosani, SJ Warrington - 2018 - europepmc.org
Dopamine, norepinephrine, and epinephrine are physiologically active molecules known as
catecholamines. Catecholamines act both as neurotransmitters and hormones vital to the …
catecholamines. Catecholamines act both as neurotransmitters and hormones vital to the …
Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo‐controlled, double‐blind …
…, KJ Baisley, SJ Warrington - British journal of clinical …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Domperidone, a dopamine antagonist
metabolized mainly by CYP3A, has been used as an anti‐emetic and prokinetic agent by …
metabolized mainly by CYP3A, has been used as an anti‐emetic and prokinetic agent by …
[HTML][HTML] A novel peptide-based pan-influenza A vaccine: a double blind, randomised clinical trial of immunogenicity and safety
…, CJ Bunce, C Horlock, JM Watson, SJ Warrington… - Vaccine, 2015 - Elsevier
Background FP-01.1 is a novel synthetic influenza A vaccine consisting of six fluorocarbon-modified
35-mer peptides that encapsulate multiple CD4+ and CD8+ T-cell epitopes and is …
35-mer peptides that encapsulate multiple CD4+ and CD8+ T-cell epitopes and is …
Pharmacokinetics, safety, and tolerability of single and multiple doses of relebactam, a β-lactamase inhibitor, in combination with imipenem and cilastatin in healthy …
…, N Calder, M Nefliu, SJ Warrington… - Antimicrobial agents …, 2018 - Am Soc Microbiol
Relebactam is a novel class A and C β-lactamase inhibitor that is being developed in
combination with imipenem-cilastatin for the treatment of serious infections with Gram-negative …
combination with imipenem-cilastatin for the treatment of serious infections with Gram-negative …
[HTML][HTML] Safety, tolerability and pharmacokinetics of FAAH inhibitor V158866: a double-blind, randomised, placebo-controlled phase I study in healthy volunteers
…, H Browne, K Donaldson, M Christie, S Warrington - Drugs in R&D, 2016 - Springer
Background and Objective The inhibition of fatty acid amide hydrolase 1 (FAAH) has been
proposed as a novel mechanism for treating pain syndromes by increasing the levels of …
proposed as a novel mechanism for treating pain syndromes by increasing the levels of …
Pharmacokinetics, metabolism, and disposition of deferasirox in β-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady …
…, U Glaenzel, K Hazell, R Sechaud, S Warrington… - Drug Metabolism and …, 2010 - ASPET
Deferasirox (ICL670) is a novel once-daily, orally administered iron chelator to treat chronic
iron overload in patients with transfusion-dependent anemias. Absorption, distribution, …
iron overload in patients with transfusion-dependent anemias. Absorption, distribution, …
Are published normal ranges of serum testosterone too high? Results of a cross‐sectional survey of serum testosterone and luteinizing hormone in healthy men
…, KJ Baisley, EV Clark, SJ Warrington - BJU …, 2004 - Wiley Online Library
OBJECTIVE To derive normal ranges of serum testosterone and luteinizing hormone (LH)
concentrations in healthy men, and thus evaluate whether testosterone replacement therapy is …
concentrations in healthy men, and thus evaluate whether testosterone replacement therapy is …
Entrustable professional activities: making sense of the emergency medicine milestones
MS Beeson, S Warrington, A Bradford-Saffles… - The Journal of …, 2014 - Elsevier
The Accreditation Council for Graduate Medical Education (ACGME) has introduced the
Next Accreditation System (NAS) with implementation for seven specialties, including …
Next Accreditation System (NAS) with implementation for seven specialties, including …