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Original Research: Ilia Volkov, Inna Rudoy, Tamar Freud, Gabriel Sardal, Sody Naimer, Roni Peleg, and Yan Press Effectiveness of Vitamin B12 in Treating Recurrent Aphthous Stomatitis: A Randomized, Double-Blind, Placebo-Controlled Trial J Am Board Fam Med 2009; 22: 9-16 [Abstract] [Full text] [PDF]

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Responses published:

I will try it!!!

Manuel Baillieau   (6 March 2009)

Methylcobalamin delivered into saliva appears more effective

Jeff T Haley   (17 February 2009)

Using B12 since at least 40 years for aphthous ulcers.

harold jitschak bueno de mesquita   (12 January 2009)

Other causes of mouth ulcers

Gordon Rafool, none   (6 January 2009)

I will try it!!! 6 March 2009
Manuel Baillieau, lawyer Send response to journal: Re: I will try it!!! asado25{at}hotmail.com Manuel Baillieau	I´ve been suffering of aphtous since I was 12, and I´ve tried everything (gel, corteroids, kanka, changing my TP). Anyway, my doctor told me about this treatment and Im gonna try it for sure!!! Thanks, and hope that works fine for everybody.
Methylcobalamin delivered into saliva appears more effective 17 February 2009
Jeff T Haley, Oral care researcher OraHealth Corporation Send response to journal: Re: Methylcobalamin delivered into saliva appears more effective Haley{at}orahealth.com Jeff T Haley	This study with 1000mcg of cyanocobalamin B12 delivered under the tongue daily showed effectiveness after 5 months. A peer-reviewed study published in the October 2008 issue of Inside Dentistry showed significant effectiveness after 4 weeks where the form of B12 was methycobalamin and 500mcg was delivered daily into saliva near the site of recurrent ulcers rather than under the tongue from an adhering disc that time released over 20-40 minutes. Several subjects (no statistics) reported effectiveness after one week. (http://orahealth.com/products/avamin_melts/science/RA_White_2008.09.08.pdf)
Using B12 since at least 40 years for aphthous ulcers. 12 January 2009
harold jitschak bueno de mesquita, physician private Send response to journal: Re: Using B12 since at least 40 years for aphthous ulcers. bdmesq{at}gmail.com harold jitschak bueno de mesquita	Dear Sir, Happy to see your article after having tried to convince so often doctors to use Vitamin B12 for this purpose [and for many more reasons but this is not the place to diverge] I remember seeing the use of B12 [with iron and/or folic acid] some 40 years ago in the BMJ or LANCET {?} Since then I have been using vitamin B12 nearly without failure for this indication and-as stated by you- mostly not dependent on blood levels. When sub lingual tablets became available in Israel [Solgar]I tried them out instead of B12 injections but nearly all patients rapidly came back because the effect was not comparable!! I also tried on a limited scale methyl-cobalamine sub lingual but probably the i.m B12 is still preferable. We now try to give patients Reuteri pearls [heat resistant probiotics] to see if we may reduce the dependency on B12 injections. Hopefully your article may have some impact on doctors who still use steroid creams/gels for this condition.
Other causes of mouth ulcers 6 January 2009
Gordon Rafool, MD none, none Send response to journal: Re: Other causes of mouth ulcers gjraf{at}aol.com Gordon Rafool, et al.	A significant cause of mouth ulcers is the chemical Sodium Lauryl Sulfate an ingredient in most tooth pastes. It is a foaming agent and detergent that is used in tooth paste. It is very harsh on the tissues in the mouth. There is a tooth paste that does not contain sodium lauryl sulfate and that is Biotene. I have changed many of my patient's to the Biotene TP and the ulcers have not re-occured. Gordon Rafool,MD