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Table 2. Commonly Used Step 2 Agents

Drug Examples of Brand Name Usual Adult Dose* Cost{dagger}

Opioid Analgesic Combination (Controlled Drug Schedule)

    Codeine/APAP (C-III) Tylenol #2 15/300, Tylenol #3 30/300, Tylenol #4 60/300; Liquid 12/120/5 mL (c-v) 60 mg q 3–4 hours or 1–2 tab q4 hours; 15 mL q 4 hours $7–14/30s$6–10/120 mL
    Codeine/aspirin (C-III) Empirin #3 30/325, Empirin #4 60/325 60 mg q 3–4 hours or 1–2 tab q 4 hours $5–8/30s
    Hydrocodone/APAP (C-III) Lorcet-HD 5/500, Lorcet plus 7.5/650, Lorcet 10/650; Lortab 2.5/500, 5/500, 7.5/500; Vicodin 5/500, Vicodin ES 7.5/750, Vicodin HP 10/660; Lortab elixir 2.5/167/5 mL 10 mg q 3–4 hours or 1–2 tab q 3–4 hours $14–25/30s
    Hydrocodone/ibuprofen (C-III){ddagger} Vicoprofen 7.5/200 1 tab q 4–6 hours $32.55/30s
    Oxycodone/APAP (C-II) Percocet 2.5/325, 5/325, 7.5/500, 10/650; Roxicet 5/325, 5/500; Tylox 5/500 10 mg q 3–4 hours $6–24/30s
    Oxycodone/aspirin (C-II) Percodan-Demi 2.5/325, Percodan 5/325 10 mg q 3–4 hours $7–17/30s
    Propoxyphene napsylate/APAP (C-IV) Darvocet-N 50 50/325, Darvocet-N 100 100/650 100 mg q 4 hours $9–16/30s
    Propoxyphene/APAP (C-IV) Wygesic 65/650 1 tab q 4 hours $6–9/30s
Other Step 2 Agents
    Tramadol{ddagger} Ultram 50 mg 50–100 mg q 4–6 hours $25/30s
    Tramadol/APAP{ddagger} Ultracet 37.5/325 1–2 tab q 4–6 hours $25/30s

* The total dose of acetaminophen or aspirin should be <4 g/day.

{dagger} Cost based on generic pricing listed in 2001 Drug Topics Redbook.

{ddagger} Not available in generic.

APAP, acetaminophen; q, every.





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