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The Journal of the American Board of Family Medicine 23 (4): 551-554 (2010)
DOI: 10.3122/jabfm.2010.04.090220
© 2010 American Board of Family Medicine
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Brief Report

Thyrotoxic Periodic Paralysis (TPP) in a 28-Year-Old Sudanese Man Started on Prednisone

Joshua J. Tessier, DO, Stacey K. Neu, MD and Kristin K. Horning, PharmD

Iowa Lutheran Family Medicine Residency, Iowa Lutheran Hospital, Des Moines (JJT, KKH, SKN), Iowa City
University of Iowa College of Pharmacy (KKH), Iowa City

Correspondence: Corresponding author: Joshua J. Tessier, DO, Iowa Lutheran Family Medicine Residency, East Des Moines Family Care Center, 840 East University Avenue, Des Moines, IA 50316 (E-mail: tessiejj{at}ihs.org)

Thyrotoxic periodic paralysis is a rare complication associated with hyperthyroidism. It is most common in the Asian population. We describe a case of a 28-year-old Sudanese man who presented with ascending lower extremity paralysis after treatment of hyperthyroidism with prednisone and methimazole. This case report reviews the literature looking at pathophysiology, causes, and treatment recommendations for this rare complication of hyperthyroidism.


Key Words: Thyrotoxic Periodic Paralysis • TPP • Prednisone • Sudanese • Case Report


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