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The Journal of the American Board of Family Medicine 21 (1): 70-74 (2008)
DOI: 10.3122/jabfm.2008.01.070091
© 2008 American Board of Family Medicine
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Brief Report

Masked Clozapine-induced Cardiomyopathy

Charles A. Pastor, MD and Monica Mehta, PharmD

Family Medicine Department, Bronx-Lebanon Hospital Center (CAP), Bronx, New York
Department of Pharmacy Practice, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University (MM), Bronx, New York

Correspondence: Corresponding author: Charles A. Pastor, MD, Department of Family Medicine, Bronx-Lebanon Hospital Center, 1276 Fulton Ave, 3rd Floor, Bronx, NY 10456 (E-mail: cpastor{at}bronxleb.org)

A 33-year-old Latin-American woman with a history of psychosis and mood disorder, but no cardiac history or risk factors, presented with heart failure after 6 weeks of clozapine and olanzapine therapy. Her presentation was ambiguous and further complicated by a highly suggestible nature, which delayed the proper diagnosis and treatment. After discontinuing the antipsychotic agents and completing an otherwise negative comprehensive work-up, her heart function significantly improved (left ventricular ejection fraction increased from 38% to 53%). A literature search showed that cardiomyopathy secondary to antipsychotics has been reported but remains poorly understood. This is the second documented case report of clozapine-induced cardiomyopathy in a Latin-American woman.




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M. A. Bowman and A. V. Neale
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J Am Board Fam Med, January 1, 2008; 21(1): 1 - 3.
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