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The Journal of the American Board of Family Practice 18:147-149 (2005)
© 2005 American Board of Family Practice


Brief Report

Excess Factor VIII: A Common Cause of Hypercoagulability

Robert S. Bobrow, MD

From the Department of Family Medicine, Stony Brook University, Stony Brook, NY

Correspondence: Address correspondence to Robert S. Bobrow, 20 Pinewood Dr., Commack, NY 11725 (e-mail: rbobrow{at}notes.cc.sunysb.edu)

Background: Elevations of coagulation factor VIII have recently been described in significant numbers of patients with venous thromboembolism (VTE) previously thought to have had an "idiopathic" event. Three patients from a family practice are presented with recurrent VTE and increased factor VIII levels.

Method: The case histories and results of laboratory tests were reviewed.

Results: The 3 patients had no other clear coagulopathy. In 2 of the 3, the increase was confirmed with a second reading.

Conclusions: Factor VIII assay should be considered in the work-up of idiopathic, recurrent VTE. Long-term anticoagulation may be appropriate in this setting.



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This article has been cited by other articles:


Home page
J Am Board Fam MedHome page
M. Hoffman
Excess Factor VIII and Hypercoagulability
J Am Board Fam Med, July 1, 2005; 18(4): 328 - 328.
[Full Text] [PDF]

Rapid Responses:

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FVIII IS an Acture Phase Reactant
Maureane Hoffman
JABFM Online, 8 Apr 2005 [Full text]
Author's response to "FVIII is an Acute Phase Reactant"
Robert S. Bobrow
JABFM Online, 11 Apr 2005 [Full text]



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