The Journal of the American Board of Family Practice, Vol 11, Issue 2 127-139, Copyright © 1998 by American Board of Family Practice

ARTICLES

The pharmacologic treatment of depression

B. A. Majeroni and A. Hess
Department of Family Medicine, State University of New York at Buffalo 14215, USA.

BACKGROUND: Family physicians often provide the first line of treatment for patients with depression. Many effective drugs are now available for the pharmacologic treatment of depression. METHODS: We searched Medline from 1991-96 under the topics of depressive disorders/treatment and antidepressant medications. Other sources were found by back-referencing from these references and from pharmacology texts. RESULTS: Although antidepressants appear to be equally effective, selective serotonin reuptake inhibitors are frequently the drugs of choice because of their safety profile the less troublesome side effects. CONCLUSIONS: When prescribing antidepressant medications, the clinician must educate patients about potential side effects and about the amount of time that must be allowed for therapeutic efficacy. Drug interactions and concurrent medical conditions are important factors in the choice of an antidepressant.

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